Severe Hypoglycemia Risk With Long-Acting Insulin Analogs vs Neutral Protamine Hagedorn Insulin.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2020.9176
Abstract: Importance Previous studies have found that the risk of severe hypoglycemia does not differ between long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes. However, these studies did not… read more here.
Keywords: insulin; risk; long acting; hypoglycemia ... See more keywords
Association of Long-Acting Injectable Antipsychotics and Oral Antipsychotics With Disease Relapse, Health Care Use, and Adverse Events Among People With Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.24163
Abstract: Key Points Question Are long-acting injectable antipsychotics (LAIAs) associated with a lower risk of disease relapse, health care use, and adverse events compared with oral antipsychotics among people in Hong Kong with schizophrenia? Findings In… read more here.
Keywords: oral antipsychotics; injectable antipsychotics; acting injectable; long acting ... See more keywords
Improving Outcomes in Schizophrenia-A Case for Initiation of Long-Acting Antipsychotics in Early-Phase Illness.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.24172
Abstract: The reduction of adverse outcomes is of crucial importance in schizophrenia, a relapsing and remitting chronic illness with a 13- to 15-year reduction in life expectancy. 1 The recurrence of acute psychotic symptoms after a… read more here.
Keywords: illness; long acting; laia treatment; risk ... See more keywords
Immediate Postpartum Long-Acting Reversible Contraceptive Use Following State-Specific Changes in Hospital Medicaid Reimbursement
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.37918
Abstract: Key Points Question Are Medicaid policies that reimburse hospitals for immediate postpartum long-acting reversible contraception (LARC) associated with increased provision of this service? Findings In this cross-sectional study of more than 3 million births in… read more here.
Keywords: postpartum; immediate postpartum; postpartum long; acting reversible ... See more keywords
Long-Acting Reversible Contraception for Adolescents: A Review
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2017.0598
Abstract: Importance Adolescents have higher rates of unintended pregnancies than any other age group. Contraceptive implants and intrauterine devices (IUDs) are long-acting reversible contraceptives (LARCs) that are known to be highly effective in preventing pregnancy. New… read more here.
Keywords: reversible contraception; long acting; acting reversible; contraceptive ... See more keywords
Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase
Sign Up to like & getrecommendations! Published in 2018 at "Chemmedchem"
DOI: 10.1002/cmdc.201800393
Abstract: Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic‐N‐carboxamide FAAH inhibitors that have… read more here.
Keywords: acid amide; bia 2474; long acting; fatty acid ... See more keywords
Population Pharmacokinetic Modeling and Simulation of TV‐46000: A Long‐Acting Injectable Formulation of Risperidone
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1078
Abstract: TV‐46000 is a long‐acting subcutaneous antipsychotic that uses a novel copolymer drug delivery technology in combination with a well‐characterized molecule, risperidone, that is in clinical development as a treatment for schizophrenia. A population pharmacokinetic (PPK)… read more here.
Keywords: 46000 long; development; population pharmacokinetic; modeling simulation ... See more keywords
Revefenacin, a Long‐Acting Muscarinic Antagonist, Does Not Prolong QT Interval in Healthy Subjects: Results of a Placebo‐ and Positive‐Controlled Thorough QT Study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.732
Abstract: Revefenacin is a novel once‐daily, lung‐selective, long‐acting muscarinic antagonist developed as a nebulized inhalation solution for the maintenance treatment of chronic obstructive pulmonary disease. In a randomized, 4‐way crossover study, healthy subjects received a single… read more here.
Keywords: muscarinic antagonist; long acting; prolong interval; healthy subjects ... See more keywords
Model‐Informed Drug Development for Long‐Acting Injectable Products: Summary of American College of Clinical Pharmacology Symposium
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.928
Abstract: Poor adherence to prescribed medications significantly impacts the U.S. health care system.1–4 Given the human and financial consequences, the development of strategies for improving adherence to prescribed medications is imperative. Long-acting injectable (LAI) drug products… read more here.
Keywords: drug development; long acting; drug; pharmacology ... See more keywords
Modeling Complex Pharmacokinetics of Long‐Acting Injectable Products Using Convolution‐Based Models With Nonparametric Input Functions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.1842
Abstract: The interest in the development and the therapeutic use of long‐acting injectable (LAI) products for chronic or long‐term treatments has grown exponentially. The complexity and the multiphase drug release process represent serious issues for an… read more here.
Keywords: long acting; convolution based; lai products; convolution ... See more keywords
Long-Acting Lipoglycopeptides Can Interfere With Vancomycin Therapeutic Drug Monitoring.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1975
Abstract: Oritavancin and dalbavancin are long-acting lipoglycopeptides with activity against susceptible gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. Though similar in structure to traditional glycopeptide antibiotics like vancomycin, these antibiotics have terminal half-lives greater than 10 days,… read more here.
Keywords: vancomycin; long acting; therapeutic drug; acting lipoglycopeptides ... See more keywords