Severe Hypoglycemia Risk With Long-Acting Insulin Analogs vs Neutral Protamine Hagedorn Insulin.
Sign Up to like & getrecommendations! Published in 2021 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2020.9176
Abstract: Importance Previous studies have found that the risk of severe hypoglycemia does not differ between long-acting insulin analogs and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes. However, these studies did not… read more here.
Keywords: insulin; risk; long acting; hypoglycemia ... See more keywords
Association of Long-Acting Injectable Antipsychotics and Oral Antipsychotics With Disease Relapse, Health Care Use, and Adverse Events Among People With Schizophrenia
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.24163
Abstract: Key Points Question Are long-acting injectable antipsychotics (LAIAs) associated with a lower risk of disease relapse, health care use, and adverse events compared with oral antipsychotics among people in Hong Kong with schizophrenia? Findings In… read more here.
Keywords: oral antipsychotics; injectable antipsychotics; acting injectable; long acting ... See more keywords
Improving Outcomes in Schizophrenia-A Case for Initiation of Long-Acting Antipsychotics in Early-Phase Illness.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.24172
Abstract: The reduction of adverse outcomes is of crucial importance in schizophrenia, a relapsing and remitting chronic illness with a 13- to 15-year reduction in life expectancy. 1 The recurrence of acute psychotic symptoms after a… read more here.
Keywords: illness; long acting; laia treatment; risk ... See more keywords
Immediate Postpartum Long-Acting Reversible Contraceptive Use Following State-Specific Changes in Hospital Medicaid Reimbursement
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.37918
Abstract: Key Points Question Are Medicaid policies that reimburse hospitals for immediate postpartum long-acting reversible contraception (LARC) associated with increased provision of this service? Findings In this cross-sectional study of more than 3 million births in… read more here.
Keywords: postpartum; immediate postpartum; postpartum long; acting reversible ... See more keywords
Long-Acting Reversible Contraception for Adolescents: A Review
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Pediatrics"
DOI: 10.1001/jamapediatrics.2017.0598
Abstract: Importance Adolescents have higher rates of unintended pregnancies than any other age group. Contraceptive implants and intrauterine devices (IUDs) are long-acting reversible contraceptives (LARCs) that are known to be highly effective in preventing pregnancy. New… read more here.
Keywords: reversible contraception; long acting; acting reversible; contraceptive ... See more keywords
Constructing a Metal–Organic Frameworks‐Based Long‐Acting Sequential Release System for the Treatment of Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202402425
Abstract: Due to the unclear pathogenesis of Alzheimer's disease (AD) and the lack of a completely cured medication, AD patients need to take medication in order and on time every day all one's life, which is… read more here.
Keywords: alzheimer disease; long acting; release; acting sequential ... See more keywords
Albumin Corona Overturns Long‐Acting Behaviors of Myristic Acid‐Conjugated Quetiapine Nanosuspension
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202500851
Abstract: This work aimed to investigate the interaction of a self‐assembled myristic acid‐conjugated quetiapine nanosuspension (QMN) with human serum albumin and its overturning effect on QMN's long‐acting performance. Albumin corona formation modified the physicochemical properties and… read more here.
Keywords: long acting; conjugated quetiapine; qmn; acid conjugated ... See more keywords
Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase
Sign Up to like & getrecommendations! Published in 2018 at "Chemmedchem"
DOI: 10.1002/cmdc.201800393
Abstract: Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic‐N‐carboxamide FAAH inhibitors that have… read more here.
Keywords: acid amide; bia 2474; long acting; fatty acid ... See more keywords
Design of a Long‐Acting Morphine Prodrug for Safe Opioid Delivery
Sign Up to like & getrecommendations! Published in 2025 at "ChemMedChem"
DOI: 10.1002/cmdc.202500499
Abstract: Effective opioid management in neonatal abstinence syndrome (NAS) and opioid use disorder (OUD) requires maintaining low, stable plasma opioid levels to prevent withdrawal without central side effects. Current treatments rely on frequent opioid dosing, such… read more here.
Keywords: morphine; design long; morphine prodrug; long acting ... See more keywords
Population Pharmacokinetic Modeling and Simulation of TV‐46000: A Long‐Acting Injectable Formulation of Risperidone
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1078
Abstract: TV‐46000 is a long‐acting subcutaneous antipsychotic that uses a novel copolymer drug delivery technology in combination with a well‐characterized molecule, risperidone, that is in clinical development as a treatment for schizophrenia. A population pharmacokinetic (PPK)… read more here.
Keywords: 46000 long; development; population pharmacokinetic; modeling simulation ... See more keywords
A Randomized Phase 1 Study Evaluating Pharmacokinetics, Safety, and Tolerability of a High‐Concentration, Long‐Acting Cabotegravir Formulation in Adults Without HIV
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.1538
Abstract: Long‐acting (LA) cabotegravir 200‐mg/mL (CAB200) injections are approved for HIV‐1 prevention and as a complete LA HIV‐1 treatment regimen with rilpivirine. A high‐concentration suspension formulation, cabotegravir 400 mg/mL (CAB400‐D), was developed to enable less frequent… read more here.
Keywords: long acting; hiv; cab400; cabotegravir ... See more keywords