Long‐Circulating Drug‐Dye‐Based Micelles with Ultrahigh pH‐Sensitivity for Deep Tumor Penetration and Superior Chemo‐Photothermal Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201906309
Abstract: The authors acknowledge the financial support of the National Key Basic Research Program (no. 2017FYA0205301 and no. 2010CB933901), the Natural Science Foundation of China (no. 81921002 and no. 81327002), and the China Postdoctoral Science Foundation… read more here.
Keywords: micelles ultrahigh; long circulating; dye based; based micelles ... See more keywords
Engineering long-circulating nanomaterial delivery systems.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2020.07.006
Abstract: One of the grand challenges at the forefront of bionanomaterials is their quick clearance in blood circulation. Progress has been made in understanding nanomaterial-biological system interactions and in developing new strategies to extend the blood… read more here.
Keywords: long circulating; engineering long; delivery systems; nanomaterial delivery ... See more keywords
Development of long-circulating docetaxel loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles: Optimization, pharmacokinetic, cytotoxicity and in vivo assessments.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.05.125
Abstract: Long-circulating nanoparticles (NPs) are promising drug delivery vehicles which target solid tumors via enhanced permeation and retention effect. Plackett-Burman (PBD) and Box-Behnken (BBD) designs were adopted to study the effects of factors viz. polymer concentration,… read more here.
Keywords: long circulating; vivo; development long; drug ... See more keywords
Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management.
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DOI: 10.1016/j.ijpharm.2021.120463
Abstract: Colorectal carcinoma is a complex malignancy and current therapies are hampered by systemic toxicity and tumor resistance to treatment. In the field of cancer therapy, copper (Cu) compounds hold great promise, with some reaching clinical… read more here.
Keywords: long circulating; circulating liposomes; colon cancer; cancer ... See more keywords
Development and In Vitro Evaluation of Long Circulating Liposomes for Targeted Delivery of Gemcitabine and Irinotecan in Pancreatic Ductal Adenocarcinoma
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DOI: 10.1208/s12249-020-01745-6
Abstract: The classically used nontargeted chemotherapeutic approach to pancreatic cancer has a dual drawback of suboptimal drug delivery at the target site and the systemic side effects produced by the unfettered exposure of the drug to… read more here.
Keywords: long circulating; gemcitabine irinotecan; petoxylated liposomes; circulating liposomes ... See more keywords
Investigation of the Antitumor Activity and Toxicity of Tumor-Derived Exosomes Fused with Long-Circulating and pH-Sensitive Liposomes Containing Doxorubicin
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112256
Abstract: Exosome–liposome hybrid nanocarriers containing chemotherapeutic agents have been developed to enhance drug delivery, improve the efficacy of the treatment of metastatic cancer, and overcome chemoresistance in cancer therapy. Thus, the objectives of this study were… read more here.
Keywords: fused long; circulating sensitive; dox; exosomes fused ... See more keywords