Long Interspersed Nuclear Elements 1 (LINE1): The chimeric transcript L1-MET and its involvement in cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.11.004
Abstract: Long interspersed nuclear elements 1 (LINE1) are non-LTR retrotransposons that represent the greatest remodeling force of the human genome during evolution. Genomically, LINE1 are constituted by a 5´ untranslated region (UTR), where the promoter regions… read more here.
Keywords: long interspersed; elements line1; line1 chimeric; nuclear elements ... See more keywords
The enhancer activity of long interspersed nuclear element derived microRNA 625 induced by NF-κB
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82735-x
Abstract: Transposable elements (TEs) are DNA sequences that cut or introduced into the genome, and they represent a massive portion of the human genome. TEs generate a considerable number of microRNAs (miRNAs) are derived from TEs… read more here.
Keywords: long interspersed; enhancer activity; binding sites; mirna 625 ... See more keywords
The differential expression of long interspersed nuclear elements‐1 as a marker for hypomethylation in Merkel cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.15265
Abstract: One side of the transparent film is adhesive, thus it can be used to cover the glass window and wrap the metal ring and the front of probe (Fig. 1a,b). The operator must ensure that… read more here.
Keywords: expression long; transparent film; interspersed nuclear; film ... See more keywords
Investigation of long interspersed element‐1 retrotransposons as potential risk factors for idiopathic temporal lobe epilepsy
Sign Up to like & getrecommendations! Published in 2021 at "Epilepsia"
DOI: 10.1111/epi.16897
Abstract: To determine if long interspersed element‐1 (L1) retrotransposons convey risk for idiopathic temporal lobe epilepsy (TLE). read more here.
Keywords: lobe epilepsy; long interspersed; element retrotransposons; idiopathic temporal ... See more keywords
Head and neck squamous cell carcinoma drives long interspersed element-1 hypomethylation in the peripheral blood mononuclear cells.
Sign Up to like & getrecommendations! Published in 2019 at "Oral diseases"
DOI: 10.1111/odi.12944
Abstract: OBJECTIVE Alteration of long interspersed element-1 (LINE-1) methylation in peripheral blood mononuclear cells (PBMCs) has been simultaneously activated to breast carcinogenesis due to its secretion. To evaluate the effect in head and neck squamous cell… read more here.
Keywords: long interspersed; line; line methylation; cell ... See more keywords
MxB inhibits long interspersed element type 1 retrotransposition
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010034
Abstract: Long interspersed element type 1 (LINE-1, also L1 for short) is the only autonomously transposable element in the human genome. Its insertion into a new genomic site may disrupt the function of genes, potentially causing… read more here.
Keywords: long interspersed; element; line; interspersed element ... See more keywords
The Human Long Interspersed Element-1 Retrotransposon: An Emerging Biomarker of Neoplasia.
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DOI: 10.1373/clinchem.2016.257444
Abstract: BACKGROUND A large portion of intronic and intergenic space in our genome consists of repeated sequences. One of the most prevalent is the long interspersed element-1 (LINE-1, L1) mobile DNA. LINE-1 is rightly receiving increasing… read more here.
Keywords: long interspersed; line; human long; biomarker ... See more keywords
Establishment of Quantitative PCR Assays for Active Long Interspersed Nuclear Element-1 Subfamilies in Mice and Applications to the Analysis of Aging-Associated Retrotransposition
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2020.519206
Abstract: The retrotransposon long interspersed nuclear element-1 (LINE-1) can autonomously increase its copy number within a host genome through the retrotransposition process. LINE-1 is active in the germline and in neural progenitor cells, and its somatic… read more here.
Keywords: copy number; long interspersed; line; retrotransposition ... See more keywords
Exonization of a deep intronic long interspersed nuclear element in Becker muscular dystrophy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.979732
Abstract: The precise identification of pathogenic DMD variants is sometimes rather difficult, mainly due to complex structural variants (SVs) and deep intronic splice-altering variants. We performed genomic long-read whole DMD gene sequencing in a boy with… read more here.
Keywords: deep intronic; interspersed nuclear; becker muscular; long interspersed ... See more keywords
Relationship between Long Interspersed Nuclear Element-1 DNA Methylation in Leukocytes and Dyslipidemia in the Japanese General Population
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Atherosclerosis and Thrombosis"
DOI: 10.5551/jat.43570
Abstract: Aim: Aberrant global DNA methylation is involved in the development of several diseases, including cardiovascular disease (CVD). We investigated whether the methylation of long interspersed nuclear element-1 (LINE-1) in leukocytes is associated with dyslipidemia, a… read more here.
Keywords: methylation; long interspersed; dna; nuclear element ... See more keywords