Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targets
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2021.12.17.473103
Abstract: MicroRNAs (miR) are important posttranscriptional regulators and exhibit a high potential to be utilized in diagnosis and therapy. However, our insufficient knowledge of the miR-mediated gene regulation in human skin wound healing severely hinders the… read more here.
Keywords: wound; small long; rna omics; long rna ... See more keywords
Abstract 5686: Long RNA sequencing of human plasma exosomes reveals full coverage of diverse protein coding and long non coding RNA
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-5686
Abstract: Growing research in oncology implicates exosomes in cell-to-cell communication and various cancer patho-physiologies. Vesicle-mediated signaling is thought to occur via both protein and RNA transport. However, there is a fundamental lack of understanding regarding the… read more here.
Keywords: long rna; plasma; rna; coverage ... See more keywords
Abstract 260: Long RNA and DNA sequencing reveals HEK293 diversity between commercial sources
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-260
Abstract: HEK293 cells are used extensively in cancer research, with more than 4800 articles between 2017 and 2022 (PubMed search “cancer[MeSH Major Topic] and hek293”). Studies involving transfection to overexpress, knock down, or modify proteins in… read more here.
Keywords: rna dna; hek293 cells; commercial sources; long rna ... See more keywords
Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels
Sign Up to like & getrecommendations! Published in 2022 at "BMC Biology"
DOI: 10.1186/s12915-022-01277-4
Abstract: Background Extracellular vesicles (EVs) are released by nearly every cell type and have attracted much attention for their ability to transfer protein and diverse RNA species from donor to recipient cells. Much attention has been… read more here.
Keywords: long rna; extracellular vesicles; lncrna transcripts; transcriptome ... See more keywords
Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis.
Sign Up to like & getrecommendations! Published in 2019 at "Clinical chemistry"
DOI: 10.1373/clinchem.2018.301291
Abstract: BACKGROUND Extracellular vesicles (EVs) contain a rich cargo of different RNA species with specialized functions and clinical applications. However, the landscape and characteristics of extracellular vesicle long RNA (exLR) in human blood remain largely unknown.… read more here.
Keywords: extracellular vesicles; long rna; diagnosis; human blood ... See more keywords
Long RNA-Mediated Chromatin Regulation in Fission Yeast and Mammals
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020968
Abstract: As part of a complex network of genome control, long regulatory RNAs exert significant influences on chromatin dynamics. Understanding how this occurs could illuminate new avenues for disease treatment and lead to new hypotheses that… read more here.
Keywords: long rna; chromatin regulation; fission yeast; regulation ... See more keywords