BCL-2: Long and winding path from discovery to therapeutic target.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.10.100
Abstract: In 1988, the BCL-2 protein was found to promote cancer by limiting cell death rather than enhancing proliferation. This discovery set the wheels in motion for an almost 30 year journey involving many international research… read more here.
Keywords: path discovery; discovery; winding path; long winding ... See more keywords
The long and winding road of designing phosphodiesterase inhibitors for the treatment of heart failure.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113123
Abstract: Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes known to play a critical role in the indirect regulation of several intracellular metabolism pathways through the selective hydrolysis of the phosphodiester bonds of specific second… read more here.
Keywords: road designing; winding road; long winding; heart failure ... See more keywords
A long and winding road: Towards a palethnograpic interpretation of the middle-Gravettian site of la Picardie (Indre-et-Loire, France)
Sign Up to like & getrecommendations! Published in 2018 at "Quaternary International"
DOI: 10.1016/j.quaint.2018.09.035
Abstract: Abstract After nine years of excavation (1998–2008) the site of La Picardie has delivered a significant lithic collection (more than 13,000 artefacts coordinated) chronologically related to the “Raysse burin” phase of the Gravettian (second phase… read more here.
Keywords: interpretation; site picardie; site; long winding ... See more keywords
The Long and Winding Road: Thoracic Myelopathy Associated With Occipitocervical Dural Arteriovenous Fistula.
Sign Up to like & getrecommendations! Published in 2017 at "World neurosurgery"
DOI: 10.1016/j.wneu.2017.09.073
Abstract: OBJECTIVES Spinal dural arteriovenous fistulas (DAVFs) have diverse presentations. Magnetic resonance imaging (MRI) reveals spinal cord swelling in only 45% to 74% of cases. We present an unusual case of a 57-year old man with… read more here.
Keywords: cord; craniocervical junction; fistula; long winding ... See more keywords
Immunotherapy biomarkers: the long and winding road
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-021-00498-w
Abstract: A recent meta-analysis examined and validated biomarkers of response to immune-checkpoint inhibitors (ICIs). Herein, we discuss the findings of this analysis, which are consistent with previously identified determinants of ICI efficacy and demonstrate that some… read more here.
Keywords: immunotherapy biomarkers; long winding; oncology; winding road ... See more keywords
A long, winding trajectory of suffering with no definite start and uncertain future prospects – narratives of individuals recently diagnosed with fibromyalgia
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Qualitative Studies on Health and Well-being"
DOI: 10.1080/17482631.2022.2056956
Abstract: ABSTRACT Purpose Fibromyalgia is a contested illness with unknown aetiology and poorly understood development. The present aim is to explore the pre-diagnostic illness trajectory narrated by individuals recently diagnosed with fibromyalgia (FM). Methods Individual interviews… read more here.
Keywords: illness; diagnosed fibromyalgia; individuals recently; long winding ... See more keywords
On a Long and Winding Road: Alloantibodies in Organ Transplantation.
Sign Up to like & getrecommendations! Published in 2023 at "Transplantation"
DOI: 10.1097/tp.0000000000004550
Abstract: Today we know that both the humoral and the cellular arm of the immune system are engaged in severe immunological challenges. A close interaction between B and T cells can be observed in most "natural"… read more here.
Keywords: winding road; road alloantibodies; long winding; transplantation long ... See more keywords
Seizure forecasting: bifurcations in the long and winding road.
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17311
Abstract: To date the unpredictability of seizures remains a source of suffering for people with epilepsy, motivating decades of research into methods to forecast seizures. Originally, only few scientists and neurologists ventured into this niche endeavor,… read more here.
Keywords: seizure; winding road; long winding; forecasting bifurcations ... See more keywords
Authors reply: The long and winding road of COVID‐19 in survivors of hospitalization
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13603
Abstract: We thank Dr. Oscar Jolobe for his insightful report [1] in response to our article [2]. Nirmatrelvir has surged as an orally administered antiviral agent that reduces coronavirus replication by inhibiting the SARS-CoV-2 3-chymotrypsin–like cysteine… read more here.
Keywords: road covid; reply long; covid survivors; winding road ... See more keywords
Repairing the effects of childhood trauma: The long and winding road.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of psychiatric and mental health nursing"
DOI: 10.1111/jpm.12581
Abstract: What is known on this subject. Domestic and family violence contributes to mental distress and the development of mental illness and can reverberate throughout a person's life. What this paper adds to existing knowledge. Therapeutic… read more here.
Keywords: trauma long; childhood trauma; effects childhood; repairing effects ... See more keywords
The long and winding road of discontinuing long-term use of antidepressants: learning from my experience.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of psychiatric and mental health nursing"
DOI: 10.1111/jpm.12623
Abstract: What is known on the subject? More people experience withdrawal symptoms when weaning off antidepressants than previously thought; particularly after taking them for a long time. What this paper adds to existing knowledge. I explore… read more here.
Keywords: discontinuing long; long winding; road discontinuing; withdrawal symptoms ... See more keywords