Downsizing the molecular spring of the giant protein titin reveals that skeletal muscle titin determines passive stiffness and drives longitudinal hypertrophy
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DOI: 10.7554/elife.40532
Abstract: Titin, the largest protein known, forms an elastic myofilament in the striated muscle sarcomere. To establish titin’s contribution to skeletal muscle passive stiffness, relative to that of the extracellular matrix, a mouse model was created… read more here.
Keywords: skeletal muscle; titin; muscle; longitudinal hypertrophy ... See more keywords