Multivariate partial linear varying coefficients model for gene‐environment interactions with multiple longitudinal traits
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9440
Abstract: Correlated phenotypes often share common genetic determinants. Thus, a multi‐trait analysis can potentially increase association power and help in understanding pleiotropic effect. When multiple traits are jointly measured over time, the correlation information between multivariate… read more here.
Keywords: varying coefficients; linear varying; coefficients model; longitudinal traits ... See more keywords
Performance Gains in Genome-Wide Association Studies for Longitudinal Traits via Modeling Time-varied effects
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00638-2
Abstract: Complex traits with multiple phenotypic values changing over time are called longitudinal traits. In traditional genome-wide association studies (GWAS) for longitudinal traits, a combined/averaged estimated breeding value (EBV) or deregressed proof (DRP) instead of multiple… read more here.
Keywords: genome wide; association studies; time; time varied ... See more keywords