Cu(I) and Cu(II) Complexes Based on Lonidamine-Conjugated Ligands Designed to Promote Synergistic Antitumor Effects
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DOI: 10.1021/acs.inorgchem.1c03658
Abstract: Bis(pyrazol-1-yl)- and bis(3,5-dimethylpyrazol-1-yl)-acetates were conjugated with the 2-hydroxyethylester and 2-aminoethylamide derivatives of the antineoplastic drug lonidamine to prepare Cu(I) and Cu(II) complexes that might act through synergistic mechanisms of action due to the presence of… read more here.
Keywords: complexes based; conjugated ligands; antitumor; based lonidamine ... See more keywords
Antitumor Effect of Lonidamine-Polypeptide-Peptide Nanoparticles in Breast Cancer Models.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b09886
Abstract: Biomaterials folded into nanoparticles (NPs) can be utilized as targeted drug delivery systems for cancer therapy. NPs may provide a vehicle for the anticancer drug lonidamine (LND), which inhibits glycolysis but was suspended from use… read more here.
Keywords: mpop nps; breast cancer; lonidamine; cancer ... See more keywords
Potentiation of the Effect of Lonidamine by Quercetin in MCF-7 human breast cancer cells through downregulation of MMP-2/9 mRNA Expression.
Sign Up to like & getrecommendations! Published in 2020 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202020200548
Abstract: Combination therapies are becoming increasingly important to develop an effective treatment in cancer. Lonidamine is frequently used in cancer treatment, but it's often preferred to be used in combination with other drugs because of its… read more here.
Keywords: combination; mcf; breast cancer; lonidamine ... See more keywords