Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes.
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DOI: 10.1158/0008-5472.can-17-3970
Abstract: Heterozygous somatic mutations in spliceosome genes (U2AF1, SF3B1, ZRSR2, or SRSF2) occur in >50% of patients with myelodysplastic syndrome (MDS). These mutations occur early in disease development, suggesting that they contribute to MDS pathogenesis and… read more here.
Keywords: loop associated; atr; dna; u2af1 s34f ... See more keywords
A Lumenal Loop Associated with Catalytic Asymmetry in Plant Vacuolar H+-Translocating Pyrophosphatase
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DOI: 10.3390/ijms222312902
Abstract: Membrane-integral inorganic pyrophosphatases (mPPases) couple pyrophosphate hydrolysis with H+ and Na+ pumping in plants and microbes. mPPases are homodimeric transporters with two catalytic sites facing the cytoplasm and demonstrating highly different substrate-binding affinities and activities.… read more here.
Keywords: plant vacuolar; lumenal loop; loop; loop associated ... See more keywords
R-Loop-Associated Genomic Instability and Implication of WRN and WRNIP1
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DOI: 10.3390/ijms23031547
Abstract: Maintenance of genome stability is crucial for cell survival and relies on accurate DNA replication. However, replication fork progression is under constant attack from different exogenous and endogenous factors that can give rise to replication… read more here.
Keywords: genomic instability; dna; replication; instability ... See more keywords