In through the out door: A loop‐binding‐first model for topological cohesin loading
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DOI: 10.1002/bies.202400120
Abstract: Cohesin is a ring‐shaped complex that is loaded on DNA in two different conformations. In one conformation, it forms loops to organize the interphase genome; in the other, it topologically encircles sibling chromosomes to facilitate… read more here.
Keywords: binding first; loop; loop binding; first model ... See more keywords
Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficits
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DOI: 10.1371/journal.pone.0211073
Abstract: Through forward genetic screening for mutations affecting visual system development, we identified prominent coloboma and cell-autonomous retinal neuron differentiation, lamination and retinal axon projection defects in eisspalte (ele) mutant zebrafish. Additional axonal deficits were present,… read more here.
Keywords: midline axon; loop binding; differentiation; binding protein ... See more keywords
The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting
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DOI: 10.3390/ijms26031359
Abstract: Dihydroorotase (DHOase; EC 3.5.2.3) is a zinc-dependent metalloenzyme that plays a key role in the de novo pyrimidine biosynthesis pathway, catalyzing the reversible cyclization of N-carbamoyl aspartate to dihydroorotate. This reaction is essential for the… read more here.
Keywords: active site; mode; loop binding; dhoase ... See more keywords