Repetitive Loop Formation by the CRISPR-Cas3 Helicase
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.430
Abstract: E. coli maintain CRISPR-Cas adaptive immune systems to protect the cell against invading genetic elements. Immunity relies on the RNA guided surveillance complex Cascade (CRISPR-associated complex for antiviral defense) and the trans-acting Cas3 protein with… read more here.
Keywords: loop formation; crispr; repetitive loop; cas3 ... See more keywords
DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06677-1
Abstract: R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability. Increased R-loops cause replication stress and chromosome fragility and have been associated with diseases… read more here.
Keywords: loop formation; rna; formation; dhx9 helicase ... See more keywords
Cotranscriptional R-loop formation by Mfd involves topological partitioning of DNA
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2019630118
Abstract: Significance R-loop structures pose a threat to genomic integrity because their formation can lead to mutagenesis. Mutagenesis drives antibiotic resistance in bacteria and chemotherapy resistance in human cancers; therefore, it is important to understand how… read more here.
Keywords: loop formation; dna; rna polymerase; formation ... See more keywords
Characterization of t-loop formation by TRF2
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DOI: 10.1080/19491034.2020.1783782
Abstract: ABSTRACT T-loops are thought to hide telomeres from DNA damage signaling and DSB repair pathways. T-loop formation requires the shelterin component TRF2, which represses ATM signaling and NHEJ. Here we establish that TRF2 alone, in… read more here.
Keywords: form loops; trf2; loop formation; characterization loop ... See more keywords
Colonoscope “Looping” During Ileo-Colonoscopy in Children is Significantly Different to that Observed in Adult Practice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pediatric Gastroenterology and Nutrition"
DOI: 10.1097/mpg.0000000000003421
Abstract: ABSTRACT Objectives: Ileo-colonoscopy (IC) can be technically challenging because of unpredictable colonoscope loop formation. Aims of this study were to assess the risk of loop formation and to attempt to understand which factors were likely… read more here.
Keywords: loop; loop formation; reverse alpha; ileo colonoscopy ... See more keywords
Loop formation and translational diffusion of intrinsically disordered proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Physical Review E"
DOI: 10.1103/physreve.100.052405
Abstract: The conformational flexibility and dynamics of unfolded peptide chains is of major interest in the context of protein folding and protein functioning. The rate with which amino acids at different positions along the peptide chain… read more here.
Keywords: loop formation; formation translational; spectroscopy; translational diffusion ... See more keywords
Sex-specific variation in R-loop formation in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010268
Abstract: R-loops are three-stranded nucleotide structures consisting of a DNA:RNA hybrid and a displaced ssDNA non-template strand. Previous work suggests that R-loop formation is primarily determined by the thermodynamics of DNA:RNA binding, which are governed by… read more here.
Keywords: formation; loop formation; sequence; drosophila melanogaster ... See more keywords
RAD51 Inhibition Induces R-Loop Formation in Early G1 Phase of the Cell Cycle
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073740
Abstract: R-loops are three-stranded structures generated by annealing of nascent transcripts to the template DNA strand, leaving the non-template DNA strand exposed as a single-stranded loop. Although R-loops play important roles in physiological processes such as… read more here.
Keywords: loop formation; phase cell; rad51 inhibition; early phase ... See more keywords
R-Loops and R-Loop-Binding Proteins in Cancer Progression and Drug Resistance
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087064
Abstract: R-loops are three-stranded DNA/RNA hybrids that form by the annealing of the mRNA transcript to its coding template while displacing the non-coding strand. While R-loop formation regulates physiological genomic and mitochondrial transcription and DNA damage… read more here.
Keywords: formation; loop formation; cancer; drug resistance ... See more keywords