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Published in 2021 at "Nature medicine"
DOI: 10.1038/s41591-021-01480-w
Abstract: Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as major depression. It could be optimized by identifying neural biomarkers that trigger therapy selectively when symptom severity is elevated. We developed an approach…
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Keywords:
depression;
loop neuromodulation;
depression closed;
stimulation ... See more keywords
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Published in 2017 at "International Review of Psychiatry"
DOI: 10.1080/09540261.2017.1282438
Abstract: Abstract Despite deep brain stimulation’s positive early results in psychiatric disorders, well-designed clinical trials have yielded inconsistent clinical outcomes. One path to more reliable benefit is closed-loop therapy: stimulation that is automatically adjusted by a…
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Keywords:
neuromodulation systems;
loop neuromodulation;
psychiatric illness;
neuromodulation ... See more keywords
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Published in 2018 at "Cold Spring Harbor perspectives in medicine"
DOI: 10.1101/cshperspect.a034314
Abstract: Neuromodulation, the focused delivery of energy to neural tissue to affect neural or physiological processes, is a common method to study the physiology of the nervous system. It is also successfully used as treatment for…
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Keywords:
loop neuromodulation;
system;
translational research;
physiological translational ... See more keywords
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Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00808
Abstract: Closed-loop or intelligent neuromodulation allows adjustable, personalized neuromodulation which usually incorporates the recording of a biomarker, followed by implementation of an algorithm which decides the timing (when?) and strength (how much?) of stimulation. Closed-loop neuromodulation…
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Keywords:
loop neuromodulation;
biomarker;
neuromodulation;
closed loop ... See more keywords