The asparagine 533 residue in the outer pore loop region of the mouse PKD2L1 channel is essential for its voltage‐dependent inactivation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12273
Abstract: Voltage‐dependent inactivation of ion channels contributes to the regulation of the membrane potential of excitable cells. Mouse polycystic kidney disease 2‐like 1 (PKD2L1) forms voltage‐dependent nonselective cation channels, which are activated but subsequently inactivated in… read more here.
Keywords: pore loop; pkd2l1; outer pore; inactivation ... See more keywords
Haplotype analysis of the mitochondrial DNA d‐loop region reveals the maternal origin and historical dynamics among the indigenous goat populations in east and west of the Democratic Republic of Congo
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.8713
Abstract: Abstract This study aimed at assessing haplotype diversity and population dynamics of three Congolese indigenous goat populations that included Kasai goat (KG), small goat (SG), and dwarf goat (DG) of the Democratic Republic of Congo… read more here.
Keywords: goat; loop region; indigenous goat; goat populations ... See more keywords
PCR-RFLP for authentication of different species of processed snappers using mitochondrial D-loop region by single enzyme
Sign Up to like & getrecommendations! Published in 2018 at "Food Control"
DOI: 10.1016/j.foodcont.2018.02.028
Abstract: Abstract A PCR-RFLP protocol was developed for authenticating nine different snapper species by targeting the 515 bp fragment in highly polymorphic mitochondrial D-loop region with a newly designed primer Fish-DL-F/Fish-DL-R, followed by restriction digestion using… read more here.
Keywords: pcr rflp; loop region; single enzyme; mitochondrial loop ... See more keywords
Polymorphisms and haplotype of mitochondrial DNA D-loop region are associated with polycystic ovary syndrome in a Chinese population.
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DOI: 10.1016/j.mito.2020.12.006
Abstract: Polymorphisms in mtDNA have been linked to a range of diseases. Here we investigate the relationship between mitochondrial DNA (mtDNA) D-loop region polymorphisms, mtDNA haplotype and polycystic ovary syndrome (PCOS), as well as the correlation… read more here.
Keywords: polycystic ovary; pcos; loop region; ovary syndrome ... See more keywords
A computational study to disclose potential drugs and vaccine ensemble for COVID-19 conundrum
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.114734
Abstract: The nucleocapsid (N) protein of SARS-COV-2, a virus responsible for the current COVID-19 pandemic, is considered a potential candidate for the design of new drugs and vaccines. The protein is central to several critical events… read more here.
Keywords: anti viral; computational study; covid; loop region ... See more keywords
Characterization of twin-cysteine motif in the V2-loop region of gp120 in primate lentiviruses.
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DOI: 10.1016/j.virol.2018.04.013
Abstract: The twin-cysteine motif (TCM) in the V2 loop region of gp120, identified in our previous report on the simian immunodeficiency virus mac239 (SIVmac239), is a conserved evolutionary element in all primate lentiviruses except for HIV-1… read more here.
Keywords: cysteine motif; region gp120; primate lentiviruses; twin cysteine ... See more keywords
Abstract P3-08-23: T146A/C and C16266T/A/G,D-loop region SNPs in mtDNA, were acted as potential targets for early breast cancer in Chinese women
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DOI: 10.1158/1538-7445.sabcs19-p3-08-23
Abstract: Purpose: Aimed to detected the association between mtDNA D-loop region nucleotide polymorphisms and prognosis of early-stage breast cancer (EBC) patients in a Chinese Han population. Material and Method: we detected 344 nucleotides in the entire… read more here.
Keywords: breast cancer; loop region; cancer; t146a c16266t ... See more keywords
Bulge-Forming miRNases Cleave Oncogenic miRNAs at the Central Loop Region in a Sequence-Specific Manner
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126562
Abstract: The selective degradation of disease-associated microRNA is promising for the development of new therapeutic approaches. In this study, we engineered a series of bulge-loop-forming oligonucleotides conjugated with catalytic peptide [(LeuArg)2Gly]2 (BC–miRNases) capable of recognizing and… read more here.
Keywords: loop region; cleavage; central loop; sequence ... See more keywords