SAFB2 Enables the Processing of Suboptimal Stem-Loop Structures in Clustered Primary miRNA Transcripts.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.05.011
Abstract: Many microRNAs (miRNAs) are generated from primary transcripts containing multiple clustered stem-loop structures that are thought to be recognized and cleaved by the Microprocessor complex as independent units. Here, we uncover an unexpected mode of… read more here.
Keywords: mirna; processing suboptimal; loop structures; stem loop ... See more keywords
Stem–Loop Structures in Iron-Regulated mRNAs of Giardia duodenalis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph20043556
Abstract: Giardia duodenalis is a significant cause of waterborne and foodborne infections, day-care center outbreaks, and traveler’s diarrhea worldwide. In protozoa such as Trichomonas vaginalis and Entamoeba histolytica, iron affects the growth, pathogenicity mechanisms, and expression… read more here.
Keywords: stem loop; iron; mrnas giardia; loop structures ... See more keywords
Accurate prediction of CDR-H3 loop structures of antibodies with deep learning
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DOI: 10.7554/elife.91512
Abstract: Accurate prediction of the structurally diverse complementarity determining region heavy chain 3 (CDR-H3) loop structure remains a primary and long-standing challenge for antibody modeling. Here, we present the H3-OPT toolkit for predicting the 3D structures… read more here.
Keywords: cdr loop; accurate prediction; loop structures; prediction ... See more keywords