Accelerating flux balance calculations in genome‐scale metabolic models by localizing the application of loopless constraints
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DOI: 10.1093/bioinformatics/bty446
Abstract: Background: Genome‐scale metabolic network models and constraint‐based modeling techniques have become important tools for analyzing cellular metabolism. Thermodynamically infeasible cycles (TICs) causing unbounded metabolic flux ranges are often encountered. TICs satisfy the mass balance and… read more here.
Keywords: genome scale; loopless constraints; flux; metabolic models ... See more keywords