Anchoring Chromatin Loops to Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.07.013
Abstract: Although some genomic rearrangements are caused by replication or transcription, the etiology of others is unclear. Reporting in Cell, Canela et al. (2017) reveal that type II topoisomerase-mediated release of torsional strain at chromosomal loop anchors… read more here.
Keywords: loops cancer; chromatin loops; anchoring chromatin; etiology ... See more keywords
Pathophysiological Role and Diagnostic Potential of R-Loops in Cancer and Beyond
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13122181
Abstract: R-loops are DNA–RNA hybrids that play multifunctional roles in gene regulation, including replication, transcription, transcription–replication collision, epigenetics, and preserving the integrity of the genome. The aberrant formation and accumulation of unscheduled R-loops can disrupt gene… read more here.
Keywords: potential loops; role; diagnostic potential; loops cancer ... See more keywords