R-Loops Promote Antisense Transcription across the Mammalian Genome
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.10.002
Abstract: Summary Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding genes in mammals and emanate from gene promoter, enhancer, and termination regions. However, their origin and biological purpose remain unclear. We show that these… read more here.
Keywords: antisense; antisense transcription; promote antisense; genome ... See more keywords
PARP1 associates with R-loops to promote their resolution and genome stability
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad066
Abstract: Abstract PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was also recently identified as a component of the R-loop-associated… read more here.
Keywords: associates loops; promote resolution; parp1; loops promote ... See more keywords