Insights into the binding properties of calf thymus DNA with lopinavir from spectroscopic and computational studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115491
Abstract: Abstract Lopinavir (LPV), an important antiviral drug, can inhibit effectively wild type and mutant HIV protease. In this work, molecular interaction mechanism between LPV and calf thymus deoxyribonucleic acid (ct-DNA) was characterized by spectroscopic, viscosity… read more here.
Keywords: lopinavir; dna; lpv dna; insights binding ... See more keywords
The effect of lopinavir/ritonavir and lopinavir/ritonavir loaded PLGA nanoparticles on experimental toxoplasmosis.
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology international"
DOI: 10.1016/j.parint.2017.08.007
Abstract: A marked reduction has been achieved in the incidence and clinical course of toxoplasmic encephalitis after the introduction of protease inhibitors within the treatment regimen of HIV (HIV-PIs). This work was undertaken to study for… read more here.
Keywords: toxoplasmosis; effect; lopinavir; hiv pis ... See more keywords
MAITRISE DE LA PREPARATION HOSPITALIERE POUR REPONDRE A UN CONTEXTE DE PENURIE : EXEMPLE DU DEVELOPPEMENT D’UNE SUSPENSION ORALE DE LOPINAVIR-RITONAVIR LORS DE LA PREMIERE VAGUE DE SARS-COV-2 EN FRANCE
Sign Up to like & getrecommendations! Published in 2021 at "Annales Pharmaceutiques Francaises"
DOI: 10.1016/j.pharma.2021.09.002
Abstract: The potential usefulness of lopinavir-ritonavir on Covid 19 infection during the first wave of contamination in France had boosted Kaletra® syrup prescription to the point of causing its national shortage. In the intensive care units… read more here.
Keywords: paration; lopinavir; lopinavir ritonavir; preparation ... See more keywords
Menthol augmented niosomes for enhanced intestinal absorption of lopinavir
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2136195
Abstract: Abstract Lopinavir is effective in treatment of HIV infection but experiences low oral bioavailability due to poor solubility, pre-systemic metabolism, and P-gp intestinal efflux. Co-processing with menthol enhanced its dissolution and intestinal permeability. Niosomes comprising… read more here.
Keywords: menthol; menthol containing; lopinavir; intestinal absorption ... See more keywords