Insights into the binding properties of calf thymus DNA with lopinavir from spectroscopic and computational studies
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.115491
Abstract: Abstract Lopinavir (LPV), an important antiviral drug, can inhibit effectively wild type and mutant HIV protease. In this work, molecular interaction mechanism between LPV and calf thymus deoxyribonucleic acid (ct-DNA) was characterized by spectroscopic, viscosity… read more here.
Keywords: lopinavir; dna; lpv dna; insights binding ... See more keywords
The effect of lopinavir/ritonavir and lopinavir/ritonavir loaded PLGA nanoparticles on experimental toxoplasmosis.
Sign Up to like & getrecommendations! Published in 2017 at "Parasitology international"
DOI: 10.1016/j.parint.2017.08.007
Abstract: A marked reduction has been achieved in the incidence and clinical course of toxoplasmic encephalitis after the introduction of protease inhibitors within the treatment regimen of HIV (HIV-PIs). This work was undertaken to study for… read more here.
Keywords: toxoplasmosis; effect; lopinavir; hiv pis ... See more keywords
MAITRISE DE LA PREPARATION HOSPITALIERE POUR REPONDRE A UN CONTEXTE DE PENURIE : EXEMPLE DU DEVELOPPEMENT D’UNE SUSPENSION ORALE DE LOPINAVIR-RITONAVIR LORS DE LA PREMIERE VAGUE DE SARS-COV-2 EN FRANCE
Sign Up to like & getrecommendations! Published in 2021 at "Annales Pharmaceutiques Francaises"
DOI: 10.1016/j.pharma.2021.09.002
Abstract: The potential usefulness of lopinavir-ritonavir on Covid 19 infection during the first wave of contamination in France had boosted Kaletra® syrup prescription to the point of causing its national shortage. In the intensive care units… read more here.
Keywords: paration; lopinavir; lopinavir ritonavir; preparation ... See more keywords
Evasion of P-gp mediated efflux and enhancement of bioavailability of protease inhibitor lopinavir by lipidic nanocarriers decorated with TPGS
Sign Up to like & getrecommendations! Published in 2025 at "Particulate Science and Technology"
DOI: 10.1080/02726351.2025.2477270
Abstract: Abstract Lopinavir (LPV) presents significant challenges in HIV management due to its poor permeability and low solubility. This study focuses on the formulation, optimization, and characterization of nanostructured lipid carriers (NLC) enriched with TPGS to… read more here.
Keywords: formulation; lpv; enhancement bioavailability; lopinavir ... See more keywords
Menthol augmented niosomes for enhanced intestinal absorption of lopinavir
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2136195
Abstract: Abstract Lopinavir is effective in treatment of HIV infection but experiences low oral bioavailability due to poor solubility, pre-systemic metabolism, and P-gp intestinal efflux. Co-processing with menthol enhanced its dissolution and intestinal permeability. Niosomes comprising… read more here.
Keywords: menthol; menthol containing; lopinavir; intestinal absorption ... See more keywords
Structure‐Guided Design and Development of a Phosphinic Lopinavir Analog as a Potent and Selective HIV‐1 Protease Inhibitor
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemistry"
DOI: 10.1155/joch/7113993
Abstract: Human immunodeficiency virus (HIV) remains a significant health issue with no vaccine available. Targeting the HIV‐1 protease (HIV‐1 PR) is essential in treatment, with inhibitors like lopinavir being historically an important component. However, lopinavir alone… read more here.
Keywords: hiv protease; pl1; hiv; lopinavir ... See more keywords