Pharmacokinetics, Safety, and Bioequivalence of 2 Lopinavir/Ritonavir (200/50 mg) Tablets in Healthy Chinese Volunteers: Effect of Food on Absorption
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DOI: 10.1002/cpdd.1229
Abstract: Lopinavir/ritonavir is an important protease inhibitor for treating HIV‐1 infection in patients aged >2 years in combination with other antiretrovirals. The antiviral activity of lopinavir/ritonavir in vivo is mainly derived from lopinavir, while ritonavir improves… read more here.
Keywords: chinese volunteers; bioequivalence; lopinavir ritonavir; healthy chinese ... See more keywords
Evaluation of retinotoxicity of COVID‐19 treatment: hydroxychloroquine and lopinavir/ritonavir
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DOI: 10.1002/jmv.26420
Abstract: Abstract Despite no established treatment for COVID‐19, hydroxychloroquine (HCQ) and lopinavir/ritonavir are being used. We read with interest the recent article of Chong et al.1 This article is protected by copyright. All rights reserved. read more here.
Keywords: hydroxychloroquine; covid; treatment; lopinavir ritonavir ... See more keywords
Clinical efficacy of Methylprednisolone and the combined use of Lopinavir/Ritonavir with Arbidol in treatment of Coronavirus Disease 2019
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DOI: 10.1002/jmv.26798
Abstract: This study aims to comparatively analyze the therapeutic efficacy upon multiple medication plans over lopinavir/ritonavir (LPV/r), arbidol (ARB), and methylprednisolone on patients with coronavirus disease 2019 (COVID‐19). Totally, 75 COVID‐19 patients admitted to The First… read more here.
Keywords: clinical efficacy; disease 2019; efficacy; coronavirus disease ... See more keywords
Drug-induced liver injury associated with lopinavir-ritonavir in patients with COVID-19: a disproportionality analysis of U.S. food and drug administration adverse event reporting system (FAERS) data
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DOI: 10.1007/s11096-021-01311-5
Abstract: Background Liver injury has been documented independently in novel coronavirus disease 2019 (COVID-19) patients and patients treated with lopinavir-ritonavir . Objective to investigate the drug-induced liver injury associated with lopinavir-ritonavir among the patients with COVID-19.… read more here.
Keywords: liver injury; drug induced; drug; induced liver ... See more keywords
Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2 In Vitro
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DOI: 10.1007/s12250-020-00288-1
Abstract: The recent outbreak of novel coronavirus pneumonia (COVID-19) caused by a new coronavirus has posed a great threat to public health. Identifying safe and effective antivirals is of urgent demand to cure the huge number… read more here.
Keywords: viral protease; lopinavir ritonavir; antiviral efficacy; protease inhibitors ... See more keywords
Lopinavir/ritonavir: Repurposing an old drug for HIV infection in COVID-19 treatment
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DOI: 10.1016/j.bj.2020.11.005
Abstract: Currently, there is no specific antiviral treatment for COVID-19. However, drugs previously developed to treat other viral infections are being tested to verify if they might also be effective against SARS-CoV-2, the virus that causes… read more here.
Keywords: treatment; infection; covid; sars cov ... See more keywords
Evaluation of Super-Boosted Lopinavir/Ritonavir in combination with Rifampin in HIV-1-infected Patients with Tuberculosis.
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DOI: 10.1016/j.ijantimicag.2019.10.021
Abstract: BACKGROUND Rifampin induces the metabolism of many medications. To overcome the reduction in serum concentrations of lopinavir/ritonavir (LPV/r) when used with rifampin, 800/200 mg or 400/400 mg doses are used. OBJECTIVES To evaluate the super-boosted… read more here.
Keywords: super boosted; hiv; mcg; rifampin ... See more keywords
Safety and efficacy of Favipiravir in moderate to severe SARS-CoV-2 pneumonia
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DOI: 10.1016/j.intimp.2021.107522
Abstract: Background We examined the safety and efficacy of a treatment protocol containing Favipiravir for the treatment of SARS-CoV-2. Methods We did a multicenter randomized open-labeled clinical trial on moderate to severe cases infections of SARS-CoV-2.… read more here.
Keywords: sars cov; moderate severe; safety efficacy; lopinavir ritonavir ... See more keywords
Effect of nevirapine, efavirenz and lopinavir/ritonavir on the therapeutic concentration and toxicity of lumefantrine in people living with HIV at Lagos University Teaching Hospital, Nigeria.
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DOI: 10.1016/j.jphs.2020.07.013
Abstract: Patients living with HIV in malarial endemic regions may experience clinically significant drug interaction between antiretroviral and antimalarial drugs. Effects of nevirapine (NVP), efavirenz (EFV) and lopinavir/ritonavir (LPVr) on lumefantrine (LM) therapeutic concentrations and toxicity… read more here.
Keywords: living hiv; efavirenz; toxicity; lopinavir ritonavir ... See more keywords
The effect of lopinavir/ritonavir and lopinavir/ritonavir loaded PLGA nanoparticles on experimental toxoplasmosis.
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DOI: 10.1016/j.parint.2017.08.007
Abstract: A marked reduction has been achieved in the incidence and clinical course of toxoplasmic encephalitis after the introduction of protease inhibitors within the treatment regimen of HIV (HIV-PIs). This work was undertaken to study for… read more here.
Keywords: toxoplasmosis; effect; lopinavir; hiv pis ... See more keywords
MAITRISE DE LA PREPARATION HOSPITALIERE POUR REPONDRE A UN CONTEXTE DE PENURIE : EXEMPLE DU DEVELOPPEMENT D’UNE SUSPENSION ORALE DE LOPINAVIR-RITONAVIR LORS DE LA PREMIERE VAGUE DE SARS-COV-2 EN FRANCE
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DOI: 10.1016/j.pharma.2021.09.002
Abstract: The potential usefulness of lopinavir-ritonavir on Covid 19 infection during the first wave of contamination in France had boosted Kaletra® syrup prescription to the point of causing its national shortage. In the intensive care units… read more here.
Keywords: paration; lopinavir; lopinavir ritonavir; preparation ... See more keywords