NSAIDs for Prophylaxis for Heterotopic Ossification After Total Hip Arthroplasty: A Bayesian Network Meta-analysis
Sign Up to like & getrecommendations! Published in 2020 at "Calcified Tissue International"
DOI: 10.1007/s00223-020-00763-7
Abstract: Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all… read more here.
Keywords: network; bayesian network; analysis; lor ... See more keywords
Better Late than Never: Adding Thiopurines After Loss of Response to Infliximab Monotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06681-w
Abstract: Since infliximab (IFX), a monoclonal antibody that specifically targets tumor necrosis factor (TNF), is efficacious and safe in the treatment for Crohn’s disease (CD), IFX therapy has become a popular choice for the induction and… read more here.
Keywords: disease; lor; thiopurine; therapy ... See more keywords
Exploring the gender gap: Letters of recommendation to pediatric surgery fellowship.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of surgery"
DOI: 10.1016/j.amjsurg.2019.08.005
Abstract: BACKGROUND Letters of recommendation (LoR) are considered one of the most important predictors of matching into a pediatric surgery fellowship. We determined if gendered differences exist in LoR written for resident candidates. METHODS A retrospective… read more here.
Keywords: surgery; letters recommendation; surgery fellowship; pediatric surgery ... See more keywords
Spontaneous recovery of traumatic brain injury-induced functional deficits is not hindered by daily administration of lorazepam
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DOI: 10.1016/j.bbr.2017.11.039
Abstract: HIGHLIGHTSThree doses of lorazepam (LOR) were chronically administered after TBI and none impaired functional recovery.LOR at 2.0 mg/kg enhanced motor function after TBI.LOR at 2.0 mg/kg enhanced spatial learning after TBI.LOR at any dose did… read more here.
Keywords: recovery; traumatic brain; lor; tbi ... See more keywords
Implementation of Neural Networks to Frontal Electroencephalography for the Identification of the Transition Responsiveness/Unresponsiveness During Induction of General Anesthesia
Sign Up to like & getrecommendations! Published in 2021 at "Irbm"
DOI: 10.1016/j.irbm.2021.02.004
Abstract: Abstract Objective General anesthesia is a reversible drug-induced state of altered arousal characterized by loss of responsiveness (LOR) due to brainstem inactivation. Precise identification of the LOR during the induction of general anesthesia is extremely… read more here.
Keywords: general anesthesia; lor; responsiveness; induction general ... See more keywords
Letters of recommendation for pediatric surgery fellowship: Analysis of linguistic differences based on gender of the applicant.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2021.02.049
Abstract: BACKGROUND Gender bias in letters of recommendation (LOR) has been reported for candidate selection in academic medicine, typically with females frequently described with communal terms (e.g. helpful, kind, interpersonal) and males described more with agentic… read more here.
Keywords: medicine; surgery fellowship; pediatric surgery; gender ... See more keywords
DOP75 Loss-of-response and immunogenicity following immunomodulator withdrawal from anti-tumour necrosis factor alpha combination therapy: Results from a large retrospective cohort study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjab073.114
Abstract: Combination therapy with anti-TNF compounds and immunomodulators (IMM; thiopurine or methotrexate) is superior to IMM or anti-TNF monotherapy in patients with inflammatory bowel disease (IBD). IMMs are frequently discontinued during the maintenance phase to mitigate… read more here.
Keywords: lor; combination therapy; imm; withdrawal ... See more keywords
P1142 Time to clinical recapture after dose escalation of subcutaneous infliximab (CT-P13 SC) following loss of response: A post hoc analysis of the 2-year Phase 3 LIBERTY-CD & LIBERTY-UC trials
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DOI: 10.1093/ecco-jcc/jjae190.1316
Abstract: Subcutaneous (SC) infliximab (IFX) is approved for the treatment of Crohn’s disease (CD) and ulcerative colitis (UC) at a dose of 120 mg every other week (EOW).1 While the effectiveness of dose escalation (DE) to… read more here.
Keywords: recapture; lor; liberty; analysis ... See more keywords
Impact of Structural Severity on Outcomes in Knee Osteoarthritis: An Analysis of Data from Phase 2 and Phase 3 Lorecivivint Clinical Trials.
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DOI: 10.1093/rheumatology/keae610
Abstract: OBJECTIVE Developing knee osteoarthritis (OA) treatments is challenging due to assessing pain and joint structure outcomes within a highly heterogeneous disease. Lorecivivint (LOR), an intra-articular (IA) CLK/DYRK inhibitor, modulates Wnt and inflammatory pathways. This review… read more here.
Keywords: lor; knee osteoarthritis; lorecivivint; pain ... See more keywords
FRI0430 THE NOVEL, INTRA-ARTICULAR CLK/DYRK1A INHIBITOR LORECIVIVINT (LOR; SM04690), WHICH MODULATES THE WNT PATHWAY, IMPROVED RESPONDER OUTCOMES IN SUBJECTS WITH KNEE OSTEOARTHRITIS: A POST HOC ANALYSIS FROM A PHASE 2B TRIAL
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.6467
Abstract: Background: Lorecivivint (LOR; SM04690) is a small-molecule, intra-articular (IA) CLK/DYRK1A inhibitor that modulates the Wnt pathway1 and has demonstrated some beneficial effects on patient-reported outcomes (PROs) relative to placebo (PBO) in two Phase 2 knee… read more here.
Keywords: samumed llc; lor; phase; post hoc ... See more keywords
Durability of Initial Platelet Count Response in Patients Treated with Avatrombopag for Immune Thrombocytopenia (ITP): Post-Hoc Results from a Phase 3 Clinical Study
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DOI: 10.1182/blood-2020-142764
Abstract: Background: The clinical management of ITP has been evolving. Thrombopoietin receptor agonists (TPO-RAs) have become widely utilized as subsequent treatments, and the 2019 ASH guidelines recommend their use over rituximab to achieve a durable response.… read more here.
Keywords: response; study; lor; itp ... See more keywords