GADD45β Loss Ablates Innate Immunosuppression in Cancer.
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DOI: 10.1158/0008-5472.can-17-1833
Abstract: T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming immune escape. Here, we identify a myeloid-intrinsic mechanism governed by the NF-κB effector molecule GADD45β that restricts tumor-associated inflammation and T-cell trafficking… read more here.
Keywords: loss ablates; gadd45; gadd45 loss; ablates innate ... See more keywords