Copy‐number analysis of Y‐linked loci in young men with non‐obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12321
Abstract: Mosaic loss of chromosome Y (mLOY) is a common feature in elderly men. If mLOY can also occur in young men, it may lead to spermatogenic failure due to loss of spermatogenic genes. Indeed, previous… read more here.
Keywords: spermatogenic failure; mosaic loss; loss chromosome; young men ... See more keywords
Effects of polycyclic aromatic hydrocarbons and multiple metals co-exposure on the mosaic loss of chromosome Y in peripheral blood.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125519
Abstract: Mosaic loss of chromosome Y (mLOY) is an indicator of genome instability, but the environmental stressors of mLOY remained largely unknown. In this study, we detected the internal exposure levels of 11 polycyclic aromatic hydrocarbon… read more here.
Keywords: mosaic loss; loss chromosome; blood; polycyclic aromatic ... See more keywords
Back to the drawing board—loss of chromosome Y (LOY) in leukocytes is associated with age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-018-0261-9
Abstract: Back to the drawing board : loss of chromosome Y (LOY) inleukocytes is associated with age-related macular degeneration read more here.
Keywords: loss chromosome; chromosome loy; board loss; associated age ... See more keywords
Mosaic loss of Y chromosome in monocytes is associated with lower survival after transcatheter aortic valve replacement
Sign Up to like & getrecommendations! Published in 2023 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehad093
Abstract: Abstract Aims Mosaic loss of Y chromosome (LOY) in blood cells is the most common acquired mutation, increases with age, and is related to cardiovascular disease. Loss of Y chromosome induces cardiac fibrosis in murine… read more here.
Keywords: loy; chromosome; aortic valve; loss chromosome ... See more keywords
Lack of age-related mosaic loss of W chromosome in long-lived birds
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2021.0553
Abstract: Females and males often exhibit different survival in nature, and it has been hypothesized that sex chromosomes may play a role in driving differential survival rates. For instance, the Y chromosome in mammals and the… read more here.
Keywords: mosaic loss; long lived; loss; age ... See more keywords
Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abn3100
Abstract: Hematopoietic mosaic loss of Y chromosome (mLOY) is associated with increased risk of mortality and age-related diseases in men, but the causal and mechanistic relationships have yet to be established. Here, we show that male… read more here.
Keywords: heart failure; loss; chromosome; mortality ... See more keywords
Mosaic loss of Y chromosome during aging
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.add0839
Abstract: Description Spread of Y chromosome aneuploidy in myeloid cells with age promotes cardiac fibrosis During their lifetimes, organisms acquire somatic mutations in individual cells caused by genomic instability, endogenous DNA replication errors, or exposure to… read more here.
Keywords: mosaic loss; myeloid cells; chromosome; stem cells ... See more keywords
Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health.
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.00008.2023
Abstract: We present a brief introduction of loss of Y chromosome (LOY) in blood, and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we… read more here.
Keywords: mosaic loss; loss; blood; loss chromosome ... See more keywords
Loss of Chromosome Y and Its Potential Applications as Biomarker in Health and Forensic Sciences
Sign Up to like & getrecommendations! Published in 2020 at "Cytogenetic and Genome Research"
DOI: 10.1159/000508564
Abstract: Loss of chromosome Y (LOY) is a mosaic aneuploidy that can be detected mainly in blood samples of male individuals. Usually, LOY occurrence increases with chronological age in healthy men. Moreover, recently LOY has been… read more here.
Keywords: chromosome potential; loss chromosome; health forensic; chromosome ... See more keywords