Loss of Dnmt3a impairs hematopoietic homeostasis and myeloid cell skewing via the PI3Kinase pathway.
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DOI: 10.1172/jci.insight.163864
Abstract: Loss-of-function mutations in the DNA methyltransferase 3A (DNMT3A) are seen in a large number of patients with acute myeloid leukemia (AML) with normal cytogenetics and are frequently associated with poor prognosis. DNMT3A mutations are an… read more here.
Keywords: cell; inhibitor treatment; pi3k inhibitor; loss ... See more keywords