HuH-7 reference genome profile: complex karyotype composed of massive loss of heterozygosity
Sign Up to like & getrecommendations! Published in 2018 at "Human Cell"
DOI: 10.1007/s13577-018-0212-3
Abstract: Human cell lines represent a valuable resource as in vitro experimental models. A hepatoma cell line, HuH-7 (JCRB0403), has been used extensively in various research fields and a number of studies using this line have… read more here.
Keywords: massive loss; cell line; line; genome profile ... See more keywords
Genomic landscape of copy number variation and copy neutral loss of heterozygosity events in equine sarcoids reveals increased instability of the sarcoid genome.
Sign Up to like & getrecommendations! Published in 2017 at "Biochimie"
DOI: 10.1016/j.biochi.2017.07.006
Abstract: Although they are the most common neoplasms in equids, sarcoids are not fully characterized at the molecular level. Therefore, the objective of this study was to characterize the landscape of structural rearrangements, such as copy… read more here.
Keywords: copy number; number variation; neutral loss; loss heterozygosity ... See more keywords
Overdominant Mutations Restrict Adaptive Loss of Heterozygosity at Linked Loci
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evab181
Abstract: Abstract Loss of heterozygosity is a common mode of adaptation in asexual diploid populations. Because mitotic recombination frequently extends the full length of a chromosome arm, the selective benefit of loss of heterozygosity may be… read more here.
Keywords: overdominant mutations; loss heterozygosity; heterozygous mutations; heterozygosity whi2 ... See more keywords
Genome-scale patterns in the loss of heterozygosity incidence in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "Genetics"
DOI: 10.1093/genetics/iyac032
Abstract: Abstract Former studies have established that loss of heterozygosity can be a key driver of sequence evolution in unicellular eukaryotes and tissues of metazoans. However, little is known about whether the distribution of loss of… read more here.
Keywords: loss heterozygosity; heterozygosity events; incidence; loss ... See more keywords
Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac214
Abstract: Abstract The appearance of genomic variations such as loss of heterozygosity (LOH) has a significant impact on phenotypic diversity observed in a population. Recent large-scale yeast population genomic surveys have shown a high frequency of… read more here.
Keywords: ploidy level; spectrum; loss heterozygosity; loh events ... See more keywords
Loss of Heterozygosity Drives Adaptation in Hybrid Yeast
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx098
Abstract: Abstract Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome… read more here.
Keywords: hybrid yeast; heterozygosity; loss heterozygosity; adaptation ... See more keywords
Aneuploidy and loss of heterozygosity as risk markers for malignant transformation in oral mucosa.
Sign Up to like & getrecommendations! Published in 2021 at "Oral diseases"
DOI: 10.1111/odi.13797
Abstract: The ability to predict malignant transformation in oral potentially malignant disorders would inform targeted treatment, provide prognostic information, and allow secondary prevention. DNA ploidy and loss of heterozygosity assays are already in clinical use and… read more here.
Keywords: transformation oral; risk; malignant transformation; loss heterozygosity ... See more keywords
CRISPR-Cas9 Editing Induces Loss of Heterozygosity in the Pathogenic Yeast Candida parapsilosis
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00393-22
Abstract: CRISPR-Cas9 has greatly streamlined gene editing and is now the gold standard and first choice for genetic engineering. However, we show that in diploid species, extra care should be taken in confirming the cause of… read more here.
Keywords: cas9; crispr cas9; loss heterozygosity; candida parapsilosis ... See more keywords
Abstract 3124: Identification of sub-clonal loss of heterozygosity (LOH) in glioblastomas analyzed with spatial transcriptomics
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3124
Abstract: We propose a method to leverage spatial transcriptomics and bioinformatic analysis to identify sub-clonal loss of heterozygosity that could otherwise be missed by standard bulk sequencing in glioblastoma tumors. Glioblastomas are highly invasive and aggressive… read more here.
Keywords: loss heterozygosity; spatial transcriptomics; sub clonal; clonal loss ... See more keywords
Radiomics method to predict loss of heterozygosity on chromosome 1p/19q of oligodendroglial tumor.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.2043
Abstract: 2043Background: Oligodendroglial tumor (OT) is one of the main types of gliomas, which is incurable in current situation. As a tumor-specific genetic alteration of OTs, loss of heterozygosity (LOH) on chromosome 1p/19q indicates a preferable… read more here.
Keywords: loss heterozygosity; chromosome 19q; radiomics method; oligodendroglial tumor ... See more keywords
Retroperitoneal paraganglioma with loss of heterozygosity of the von Hippel-Lindau gene: a case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrine journal"
DOI: 10.1507/endocrj.ej21-0611
Abstract: Von Hippel-Lindau (VHL) disease is an autosomal dominant disease related to germline mutations in VHL. In VHL disease, pheochromocytoma develops in 10%-20% of patients because of germline mutations and loss of heterozygosity of VHL. However,… read more here.
Keywords: loss heterozygosity; retroperitoneal paraganglioma; loss; paraganglioma ... See more keywords