Curcumin represses mTORC1 signaling in Caco-2 cells by a two-sided mechanism involving the loss of IRS-1 and activation of AMPK.
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DOI: 10.1016/j.cellsig.2020.109842
Abstract: The mechanistic target of rapamycin complex 1 (mTORC1) is a central modulator of inflammation and tumorigenesis in the gastrointestinal tract. Growth factors upregulate mTORC1 via the PI3K/AKT and/or Ras/MAPK signal pathways. Curcumin (CUR), a polyphenol… read more here.
Keywords: caco cells; mtorc1 signaling; mechanism; loss irs ... See more keywords