Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15962-x
Abstract: The thymus is a primary lymphoid organ that plays an essential role in T lymphocyte maturation and selection during development of one arm of the mammalian adaptive immune response. Although transcriptional mechanisms have been well… read more here.
Keywords: rna misprocessing; mbnl1; induces rna; blood ... See more keywords
Alternative splicing mediates the compensatory upregulation of MBNL2 upon MBNL1 loss-of-function
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1219
Abstract: Abstract Loss of gene function can be compensated by paralogs with redundant functions. An example of such compensation are the paralogs of the Muscleblind-Like (MBNL) family of RNA-binding proteins that are sequestered and lose their… read more here.
Keywords: function; mbnl1 loss; loss; mbnl2 ... See more keywords