Frequent loss of metastatic ability in subclones of Apc, Kras, Tgfbr2, and Trp53 mutant intestinal tumor organoids
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DOI: 10.1111/cas.15709
Abstract: Cancer evolution is explained by the accumulation of driver mutations and subsequent positive selection by acquired growth advantages, like Darwin's evolution theory. However, whether the negative selection of cells that have lost malignant properties contributes… read more here.
Keywords: ability; metastatic ability; tumor; loss metastatic ... See more keywords