Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR—final report from AFTER-SKI
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DOI: 10.1038/s41375-021-01173-w
Abstract: Discontinuation of tyrosine kinase inhibitor (TKI) treatment for chronic phase (CP) CML patients with a deep molecular response (DMR) has entered standard practice. This is based on numerous clinical studies showing that ~50% of patients… read more here.
Keywords: euro ski; cml; loss mmr; discontinuation ... See more keywords
Morphological predictors for microsatellite instability in urothelial carcinoma
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DOI: 10.1186/s13000-021-01168-2
Abstract: Introduction Microsatellite instability occurs due to a series of mutations in the DNA pairing error repair (Mismatch repair; MMR) genes, which can affect germ cells as occurs in Lynch syndrome, whose patients are at high… read more here.
Keywords: instability; urothelial carcinomas; loss mmr; mmr protein ... See more keywords
Clinicopathological characteristics and loss of mismatch repair protein expression in Chinese upper tract urothelial carcinomas
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DOI: 10.3389/fonc.2022.1012168
Abstract: Expression of DNA mismatch repair (MMR) protein (MLH1, PMS2, MSH2, and MSH6) in upper tract urothelial carcinoma (UTUC) has been explored in Western cohorts, but it is rarely reported in Eastern cohorts. We aimed to… read more here.
Keywords: loss mmr; protein expression; loss; expression ... See more keywords