Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition
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DOI: 10.1158/0008-5472.can-22-0883
Abstract: A kinase inhibitor screen identifies SYK as a targetable vulnerability in melanoma cells with NF1 loss of function. read more here.
Keywords: melanoma; nf1 melanoma; loss nf1; kinase ... See more keywords
Abstract 1726: Loss of NF1 drives hormone dependent mammary carcinogenesis in a rat model with intact immune system
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DOI: 10.1158/1538-7445.am2023-1726
Abstract: Loss of NF1 plays a major role as an oncogenic driver in up to 33% of all breast cancers (BC). Loss of NF1 is also a prognostic indicator for increased cancer risk at an earlier… read more here.
Keywords: nf1; loss nf1; loss; model ... See more keywords