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   Articles with "loss primary" as a keyword



Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

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recommendations! Published in 2025 at "Molecular Oncology"

DOI: 10.1002/1878-0261.70057

Abstract: Endothelial‐to‐mesenchymal transition (EndMT) is closely associated with tumor progression. Endothelial cells (ECs) in the tumor microenvironment (TME) use EndMT programs to facilitate tumor progression; however, the underlying mechanisms in ovarian cancer are poorly understood. Here,… read more here.

Keywords: mesenchymal transition; tumor microenvironment; primary cilia; tumor ... See more keywords

Weight loss in primary care: A pooled analysis of two pragmatic cluster‐randomized trials

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recommendations! Published in 2021 at "Obesity"

DOI: 10.1002/oby.23292

Abstract: The aim of this study was to report the results of five weight‐loss interventions in primary care settings in underserved patients and to compare the level of pragmatism across the interventions using the Pragmatic Explanatory… read more here.

Keywords: care pooled; primary care; loss primary; weight loss ... See more keywords

Long-term space changes after premature loss of a primary maxillary first molar

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recommendations! Published in 2017 at "Journal of Dental Sciences"

DOI: 10.1016/j.jds.2016.06.005

Abstract: Background/purpose The consequence of premature loss of primary teeth resulting in the need for space maintainers has been controversial for many years. There is no longitudinal long-term report in literature regarding the premature loss of… read more here.

Keywords: loss primary; first molar; primary maxillary; premature loss ... See more keywords

Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-89933-7

Abstract: Loss of primary cilia in cells deficient for the tumor suppressor von Hippel Lindau (VHL) arise from elevated Aurora Kinase A (AURKA) levels. VHL in its role as an E3 ubiquitin ligase targets AURKA for… read more here.

Keywords: akt; loss primary; signaling node; primary cilia ... See more keywords

Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson’s disease

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2402206121

Abstract: Significance Activating mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s and block primary cilia formation in specific cells in the mouse brain. Here, we report the same cell-type-specific cilia loss in postmortem brain from… read more here.

Keywords: primary cilia; loss primary; cilia dopaminergic; lrrk2 ... See more keywords
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Prevalence of early loss of primary molar and its impact in schoolchildren's quality of life

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recommendations! Published in 2018 at "International Journal of Paediatric Dentistry"

DOI: 10.1111/ipd.12416

Abstract: BACKGROUND Evidence regarding the impact of premature loss of primary molars on oral health-related quality of life (OHRQoL) is lacking. AIM To evaluate the prevalence of premature loss of primary molars in schoolchildren and its… read more here.

Keywords: loss primary; primary molars; early loss; prevalence early ... See more keywords

Diagnosis and initial management of children presenting with premature loss of primary teeth associated with a systemic condition: A scoping review and development of clinical aid.

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recommendations! Published in 2024 at "International journal of paediatric dentistry"

DOI: 10.1111/ipd.13188

Abstract: BACKGROUND Premature loss of primary teeth (PLPT) can be a rare presentation of systemic medical conditions. Premature loss of primary teeth may present a diagnostic dilemma to paediatric dentists. AIMS To identify systemic conditions associated… read more here.

Keywords: aid; clinical aid; premature loss; loss primary ... See more keywords

Assessment of space changes in the lower dental arch after the premature unit loss of a primary molar: A randomized clinical trial.

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recommendations! Published in 2024 at "International journal of paediatric dentistry"

DOI: 10.1111/ipd.13239

Abstract: BACKGROUND Premature loss of primary teeth presents a significant challenge in oral health, with conflicting views on using space maintainers. AIM To assess mandibular arch space changes associated with premature lower primary molar (PM) loss… read more here.

Keywords: loss; premature; space; arch ... See more keywords

HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma

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recommendations! Published in 2017 at "EMBO reports"

DOI: 10.15252/embr.201541922

Abstract: Loss of primary cilia is frequently observed in tumor cells, including pancreatic ductal adenocarcinoma (PDAC) cells, suggesting that the absence of this organelle may promote tumorigenesis through aberrant signal transduction and the inability to exit… read more here.

Keywords: loss primary; hdac2; pdac cells; primary cilia ... See more keywords