The interplay between aging‐associated loss of protein homeostasis and extracellular vesicles in neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24526
Abstract: The finding of an effective cure or treatment for neurodegenerative diseases is one of the biggest challenges for this century. Although these diseases show different clinical manifestations, the presence of toxic protein aggregates in the… read more here.
Keywords: protein; extracellular vesicles; protein homeostasis; loss protein ... See more keywords
Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.01.019
Abstract: Loss of the ataxia-telangiectasia mutated (ATM) kinase causes cerebellum-specific neurodegeneration in humans. We previously demonstrated that deficiency in ATM activation via oxidative stress generates insoluble protein aggregates in human cells, reminiscent of protein dysfunction in… read more here.
Keywords: protein; poly adp; loss protein; deficiency ... See more keywords
Loss of PROTEIN TARGETING TO STARCH 2 has variable effects on starch synthesis across organs and species
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/erac268
Abstract: Loss of PTST2, a protein involved in starch granule initiation, had highly variable effects between three grass species on carbohydrate metabolism and physiology of leaves and granule morphology of seeds. read more here.
Keywords: protein targeting; variable effects; loss protein; loss ... See more keywords