Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith–Magenis syndrome
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DOI: 10.1073/pnas.2210122119
Abstract: Significance Smith–Magenis syndrome (SMS) is a neurodevelopmental disorder associated with autism and epileptic seizures. SMS is caused by losing one copy of the gene encoding retinoic acid induced 1 (RAI1), a ubiquitously expressed transcriptional regulator.… read more here.
Keywords: smith magenis; loss rai1; mouse; excitability ... See more keywords