The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
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DOI: 10.1016/j.neuron.2020.03.005
Abstract: DNA sequence variants in the TBK1 gene associate with or cause sporadic or familial amyotrophic lateral sclerosis (ALS). Here we show that mice bearing human ALS-associated TBK1 missense loss-of-function mutations, or mice in which the… read more here.
Keywords: kinase activity; loss tbk1; motor neurons; tbk1 kinase ... See more keywords