Bioconversion of lovastatin to simvastatin by Streptomyces carpaticus toward the inhibition of HMG-CoA activity.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2429
Abstract: The aim of this study was the modification of lovastatin by microbes to improve its potential. Actinobacteria exhibit staggering diversity in terms of their biosynthetic capability for specialized metabolites which has been traced back to… read more here.
Keywords: hmg coa; analysis; simvastatin; lovastatin ... See more keywords
Evaluating the outcomes of submerged co-cultivation: production of lovastatin and other secondary metabolites by Aspergillus terreus in fungal co-cultures
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09874-0
Abstract: The goal of the study was to compare the production of secondary metabolites by Aspergillus terreus ATCC 20542 under the conditions of submerged mono- and co-cultivation. The suggested experimental scheme encompassed a diverse set of… read more here.
Keywords: production; metabolites aspergillus; cultivation; lovastatin ... See more keywords
Optimization of lovastatin production by Aspergillus terreus ATCC 10020 using solid-state fermentation and its pharmacological applications
Sign Up to like & getrecommendations! Published in 2021 at "Biocatalysis and agricultural biotechnology"
DOI: 10.1016/j.bcab.2021.101906
Abstract: Abstract Lovastatin is a potent hypocholesteremic drug. In this study lovastatin production from Aspergillus terreus ATCC 10020 was optimized using solid state fermentation with wheat bran. Incubation time, incubation temperature, initial moisture content, inoculum size,… read more here.
Keywords: aspergillus terreus; production aspergillus; lovastatin production; terreus atcc ... See more keywords
An overview on the biological activity and anti-cancer mechanism of lovastatin.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110122
Abstract: Lovastatin, a secondary metabolite isolated from fungi, is often used as a representative drug to reduce blood lipid concentration and treat hypercholesterolemia. Its structure is similar to that of HMG-CoA. Lovastatin inhibits the binding of… read more here.
Keywords: biological activity; lovastatin; effect; cancer ... See more keywords
Effect of acute and chronic exposure to lovastatin on the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174290
Abstract: Numerous studies indicate neuroprotective activity of statins, commonly used cholesterol lowering drugs in epilepsy and several other neurological diseases. Promising anti-convulsant and neuroprotective effects of statins, attributed to their anti-excitotoxic and anti-inflammatory action were reported… read more here.
Keywords: valproate; lovastatin; effect; antiepileptic drugs ... See more keywords
The role of lovastatin in the attenuation of COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2021.108192
Abstract: The mounting evidence regarding the pathogenesis of COVID-19 indicated that the cytokine storm has an axial role in the severity of this disease, which may lead to thrombotic complications, acute respiratory distress syndrome (ARDS), and… read more here.
Keywords: control; group; lovastatin; covid ... See more keywords
Ultrasonic Irradiation Enables Facile Production of Lovastatin from Sugar Cane Bagasse
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c06221
Abstract: This study investigated the effect of ultrasound-assisted hydrogen peroxide (H2O2) pretreatment on sugar cane bagasse (SCB) followed by Monascus purpureus TISTR 3003 cultivation for lovastatin production under solid-state fermentation (SSF). Optimization of the pretreatment conditions… read more here.
Keywords: sugar cane; cane bagasse; production; lovastatin ... See more keywords
Optimization of Conditions for Production of Lovastatin, A Cholesterol Lowering Agent, from a Novel Endophytic Producer Meyerozyma guilliermondii
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biologically Active Products from Nature"
DOI: 10.1080/22311866.2020.1768147
Abstract: Abstract Lovastatin production through submerged fermentation has been widely studied while there are very few reports on the same through Solid State Fermentation (SSF). This study attempts to investigate the effect of various fermentation process… read more here.
Keywords: production; wheat bran; lovastatin; optimization ... See more keywords
Results from a Double-Blind, Randomized, Placebo-Controlled, Single-Dose, Crossover Trial of Lovastatin or Minocycline in Fragile X Syndrome
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Child and Adolescent Psychopharmacology"
DOI: 10.1089/cap.2024.0103
Abstract: Introduction: Treatment studies in FMR1 knockout rodent models have found that minocycline and lovastatin each improve synaptic, neurological, and behavioral functioning, and open-label chronic dosing studies in human patients with fragile X syndrome (FXS) have… read more here.
Keywords: double blind; single dose; minocycline; placebo ... See more keywords
Lovastatin‐mediated MCF‐7 cancer cell death involves LKB1‐AMPK‐p38MAPK‐p53‐survivin signalling cascade
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14879
Abstract: There is increasing evidence that statins, which are widely used in lowering serum cholesterol and the incidence of cardiovascular diseases, also exhibits anti‐tumour properties. The underlying mechanisms by which statins‐induced cancer cell death, however, remain… read more here.
Keywords: lovastatin; cell death; cancer; p53 ... See more keywords
The Role of LaeA and LovE Regulators in Lovastatin Biosynthesis with Exogenous Polyamines in Aspergillus terreus
Sign Up to like & getrecommendations! Published in 2019 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683819060176
Abstract: The filamentous fungus Aspergillus terreus is the main industrial producer of a cholesterol-lowering drug, lovastatin, and simvastatin obtained on its basis. The biosynthesis of lovastatin in A. terreus is under the control of two major… read more here.
Keywords: aspergillus terreus; love; lovastatin biosynthesis; laea ... See more keywords