Signal Propagation in Sensing and Reciprocating Cellular Systems with Spatial and Structural Heterogeneity
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-018-0439-x
Abstract: Sensing and reciprocating cellular systems (SARs) are important for the operation of many biological systems. Production in interferon (IFN) SARs is achieved through activation of the Jak-Stat pathway, and downstream upregulation of IFN regulatory factor… read more here.
Keywords: sensing reciprocating; heterogeneity; reciprocating cellular; cellular systems ... See more keywords
Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding.
Sign Up to like & getrecommendations! Published in 2020 at "Structure"
DOI: 10.1016/j.str.2020.03.001
Abstract: Antibody structure couples adaptive and innate immunity via Fab (antigen binding) and Fc (effector) domains that are connected by unique hinge regions. Because antibodies harbor two or more Fab domains, they are capable of crosslinking… read more here.
Keywords: induced allosteric; low affinity; antigen; antigen induced ... See more keywords
Allosteric Modulation of Membrane Proteins by Small Low-Affinity Ligands
Sign Up to like & getrecommendations! Published in 2023 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c01542
Abstract: Membrane proteins may respond to a variety of ligands under an applied external stimulus. These ligands include small low-affinity molecules that account for functional effects in the mM range. Understanding the modulation of protein function… read more here.
Keywords: membrane proteins; affinity; low affinity; affinity ligands ... See more keywords
Partition of Amphiphilic Molecules to Lipid Bilayers by ITC: Low-Affinity Solutes
Sign Up to like & getrecommendations! Published in 2017 at "ACS Omega"
DOI: 10.1021/acsomega.7b01145
Abstract: A protocol is developed to allow the accurate characterization of partition to lipid bilayers for solutes with low affinity, using isothermal titration calorimetry. The methodology proposed is suitable for studies using complex membranes, such as… read more here.
Keywords: methodology; lipid bilayers; partition amphiphilic; low affinity ... See more keywords
Affinity-optimizing enhancer variants disrupt development
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-023-06922-8
Abstract: Enhancers control the location and timing of gene expression and contain the majority of variants associated with disease1–3. The ZRS is arguably the most well-studied vertebrate enhancer and mediates the expression of Shh in the… read more here.
Keywords: low affinity; gene expression; enhancer; affinity ... See more keywords
Improved methods for the detection of histone interactions with peptide microarrays
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42711-y
Abstract: Histone post-translational modifications contribute to chromatin function largely through the recruitment of effector proteins that contain specialized “reader” domains. While a significant number of reader domains have been characterized for their histone binding specificities, many… read more here.
Keywords: detection; histone interactions; reader; low affinity ... See more keywords
Extended-ensemble docking to probe dynamic variation of ligand binding sites during large-scale structural changes of proteins
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc00841f
Abstract: Proteins can sample a broad landscape as they undergo conformational transition between different functional states. At the same time, as key players in almost all cellular processes, proteins are important drug targets. Considering the different… read more here.
Keywords: ensemble docking; extended ensemble; affinity; large scale ... See more keywords
Quantification of Low Affinity Binding Interactions between Natural Killer Cell Inhibitory Receptors and Targeting Ligands with a Self-Induced Back-Action Actuated Nanopore Electrophoresis (SANE) Sensor.
Sign Up to like & getrecommendations! Published in 2020 at "Nanotechnology"
DOI: 10.1088/1361-6528/abbf26
Abstract: A plasmonic nanopore sensor enabling detection of bimodal optical and electrical molecular signatures was fabricated and tested for its ability to characterize low affinity ligand-receptor interactions. This plasmonic nanosensor uses Self-Induced Back-Action (SIBA) for optical… read more here.
Keywords: sane; low affinity; receptor; ligand ... See more keywords
NO3- , PO43- and SO42- deprivation reduced LKT1-mediated low-affinity K+ uptake and SKOR-mediated K+ translocation in tomato and Arabidopsis plants.
Sign Up to like & getrecommendations! Published in 2017 at "Physiologia plantarum"
DOI: 10.1111/ppl.12558
Abstract: Regulation of essential macronutrients acquisition by plants in response to their availability is a key process for plant adaptation to changing environments. Here we show in tomato and Arabidopsis plants that when they are subjected… read more here.
Keywords: affinity uptake; tomato; low affinity; translocation ... See more keywords
684 A low affinity bivalent mesothelin-binding MATCH4 multispecific T cell engager increases cytotoxic selectivity for high mesothelin expressing cells
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0684
Abstract: Background The effective treatment of solid tumors remains an unmet medical need. Several concepts exist to treat malignancies, including antibody-drug or -immunotoxin conjugates, immune checkpoint inhibition, CAR- T cells, as well as bispecific T cell… read more here.
Keywords: affinity; affinity bivalent; low affinity; cell ... See more keywords
Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-18-2559
Abstract: Purpose: Targeting nonspecific, tumor-associated antigens (TAA) with chimeric antigen receptors (CAR) requires specific attention to restrict possible detrimental on-target/off-tumor effects. A reduced affinity may direct CAR-engineered T (CAR-T) cells to tumor cells expressing high TAA… read more here.
Keywords: low affinity; car cells; affinity; chimeric antigen ... See more keywords