Pervasive Selection for Clinically Relevant Resistance and Media Adaptive Mutations at Very Low Antibiotic Concentrations
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad010
Abstract: Abstract Experimental evolution studies have shown that weak antibiotic selective pressures (i.e., when the antibiotic concentrations are far below the minimum inhibitory concentration, MIC) can select resistant mutants, raising several unanswered questions. First, what are… read more here.
Keywords: antibiotic concentrations; adaptive mutations; low antibiotic; resistance ... See more keywords
Cryptic β-Lactamase Evolution Is Driven by Low β-Lactam Concentrations
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00108-21
Abstract: Very low antibiotic concentrations have been shown to drive the evolution of antimicrobial resistance. While substantial progress has been made to understand the driving role of low concentrations during resistance development for different antimicrobial classes,… read more here.
Keywords: lactam concentrations; antibiotic concentrations; low antibiotic; resistance ... See more keywords