Severe asthma: what is new in the new millennium.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000623
Abstract: PURPOSE OF REVIEW Severe asthma remains a debilitating disease and a challenge for the clinicians. Novel therapies have been introduced and have greatly improved asthma control and more are under development or in clinical studies.… read more here.
Keywords: severe asthma; asthma new; asthma; new new ... See more keywords
Identification and treatment of T2-low asthma in the era of biologics
Sign Up to like & getrecommendations! Published in 2020 at "ERJ Open Research"
DOI: 10.1183/23120541.00309-2020
Abstract: Currently, and based on the development of relevant biologic therapies, T2-high is the most well-defined endotype of asthma. Although much progress has been made in elucidating T2-high inflammation pathways, no specific clinically applicable biomarkers for… read more here.
Keywords: inflammation; biologic agents; low asthma; treatment low ... See more keywords
Mitochondria dysfunction in airway epithelial cells is associated with type 2-low asthma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1186317
Abstract: Background: Type 2 (T2)-low asthma can be severe and corticosteroid-resistant. Airway epithelial cells play a pivotal role in the development of asthma, and mitochondria dysfunction is involved in the pathogenesis of asthma. However, the role… read more here.
Keywords: airway epithelial; asthma; low asthma; degs ... See more keywords
Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1107031
Abstract: Introduction Asthma is primarily divided into two categories: type 2 (T2-high) and non-type 2 (T2-low). A relationship between asthma severity and vitamin D deficiency has been identified, but its impact on each asthma endotype remains… read more here.
Keywords: effects vitamin; airway obstruction; asthma endotypes; asthma ... See more keywords
T2-Low Asthma: A Discussed but Still Orphan Disease
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11041226
Abstract: Asthma affects 10% of the worldwide population; about 5% of cases are severe with the need for target therapies such as biologics. All the biologics approved for asthma hit the T2 pathway of inflammation. T2-high… read more here.
Keywords: asthma; discussed still; low asthma; orphan disease ... See more keywords
Inflammation in Asthma: Mechanistic Insights and the Role of Biologics in Therapeutic Frontiers
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13061342
Abstract: Asthma is a chronic and multifaceted respiratory condition that affects over 300 million individuals across the globe. It is characterized by persistent inflammation of the airways, which leads to episodes of wheezing, breathlessness, chest tightness,… read more here.
Keywords: high asthma; low asthma; inflammation asthma; asthma mechanistic ... See more keywords