Severe asthma: what is new in the new millennium.
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000623
Abstract: PURPOSE OF REVIEW Severe asthma remains a debilitating disease and a challenge for the clinicians. Novel therapies have been introduced and have greatly improved asthma control and more are under development or in clinical studies.… read more here.
Keywords: severe asthma; asthma new; asthma; new new ... See more keywords
Identification and treatment of T2-low asthma in the era of biologics
Sign Up to like & getrecommendations! Published in 2020 at "ERJ Open Research"
DOI: 10.1183/23120541.00309-2020
Abstract: Currently, and based on the development of relevant biologic therapies, T2-high is the most well-defined endotype of asthma. Although much progress has been made in elucidating T2-high inflammation pathways, no specific clinically applicable biomarkers for… read more here.
Keywords: inflammation; biologic agents; low asthma; treatment low ... See more keywords
Mitochondria dysfunction in airway epithelial cells is associated with type 2-low asthma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1186317
Abstract: Background: Type 2 (T2)-low asthma can be severe and corticosteroid-resistant. Airway epithelial cells play a pivotal role in the development of asthma, and mitochondria dysfunction is involved in the pathogenesis of asthma. However, the role… read more here.
Keywords: airway epithelial; asthma; low asthma; degs ... See more keywords
Evaluating the effects of vitamin D Level on airway obstruction in two asthma endotypes in humans and in two mouse models with different intake of vitamin D during early-life
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1107031
Abstract: Introduction Asthma is primarily divided into two categories: type 2 (T2-high) and non-type 2 (T2-low). A relationship between asthma severity and vitamin D deficiency has been identified, but its impact on each asthma endotype remains… read more here.
Keywords: effects vitamin; airway obstruction; asthma endotypes; asthma ... See more keywords
T2-Low Asthma: A Discussed but Still Orphan Disease
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DOI: 10.3390/biomedicines11041226
Abstract: Asthma affects 10% of the worldwide population; about 5% of cases are severe with the need for target therapies such as biologics. All the biologics approved for asthma hit the T2 pathway of inflammation. T2-high… read more here.
Keywords: asthma; discussed still; low asthma; orphan disease ... See more keywords