Chimeric PD-1:28 Receptor Upgrades Low-Avidity T cells and Restores Effector Function of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-1922
Abstract: Inherent intermediate- to low-affinity T-cell receptors (TCR) that develop during the natural course of immune responses may not allow sufficient activation for tumor elimination, making the majority of T cells suboptimal for adoptive T-cell therapy… read more here.
Keywords: avidity cells; low avidity; function; cell ... See more keywords
Abstract 608: Low avidity neoepitope-specific CD8+ tumor infiltrating lymphocytes are less exhausted and more effective than their high avidity counterparts in a BALB/c murine fibrosarcoma
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-608
Abstract: The frequency of CD8+ tumor infiltrating lymphocytes (TILs) has been positively associated with overall survival in several cancers. The interaction of T cell receptors (TCRs) on T cells with Major Histocompatibility Complex (MHC)-peptide complexes on… read more here.
Keywords: low avidity; high avidity; term; cd8 tils ... See more keywords
Detection of persistent low IgG avidity–an interpretative problem in the diagnosis of acute toxoplasmosis
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DOI: 10.1371/journal.pone.0284499
Abstract: Objectives For the proper diagnosis of toxoplasmosis it is essential to determine the stage of the infection, for which the most preferred method is IgG avidity test. The avidity index (AI) should initially be low… read more here.
Keywords: acute toxoplasmosis; toxoplasmosis; low avidity; igg avidity ... See more keywords
Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma
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DOI: 10.3389/fimmu.2019.02115
Abstract: The efficacy of T cells depends on their functional avidity, i. e., the strength of T cell interaction with cells presenting cognate antigen. The overall T cell response is composed of multiple T cell clonotypes,… read more here.
Keywords: cell responses; avidity; avidity cells; high avidity ... See more keywords