Utility of Naltrexone Treatment for Chronic Inflammatory Dermatologic Conditions: A Systematic Review
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Dermatology"
DOI: 10.1001/jamadermatol.2018.4093
Abstract: Importance Dermatology is encountering increasing rates of autoimmune disease manifesting in primary skin conditions that are difficult to treat without a risk of immunosuppression. Naltrexone is an orally active opioid antagonist that influences a variety… read more here.
Keywords: low dose; dermatology; treatment; dose naltrexone ... See more keywords
Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2018.4222
Abstract: Importance Antidepressants at low dose are commonly prescribed for the management of chronic low back pain and their use is recommended in international clinical guidelines. However, there is no evidence for their efficacy. Objective To… read more here.
Keywords: low dose; back pain; low back; dose amitriptyline ... See more keywords
Association of Long-term Use of Low-Dose Aspirin as Chemoprevention With Risk of Lung Cancer
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.0185
Abstract: Key Points Question Is long-term use of low-dose aspirin associated with reduced risk of lung cancer, and if so, which populations may derive the greatest benefit? Findings This cohort study using data from 12 969 400 participants… read more here.
Keywords: risk; low dose; dose aspirin; lung cancer ... See more keywords
Comparison of Risk of Recrudescent Fever in Children With Kawasaki Disease Treated With Intravenous Immunoglobulin and Low-Dose vs High-Dose Aspirin
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.18565
Abstract: Key Points Question Is initial treatment with low-dose aspirin, along with intravenous immunoglobulin, for children with Kawasaki disease associated with an increase in recrudescent fever? Findings In this cohort study of 260 children with Kawasaki… read more here.
Keywords: intravenous immunoglobulin; children kawasaki; low dose; kawasaki disease ... See more keywords
Aspirin for Primary Prevention-Time to Rethink Our Approach.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.10144
Abstract: Over the past decades, the medical community has witnessed a significant improvement in cardiovascular disease (CVD) outcomes. Nonetheless, CVD remains a leading cause of morbidity and mortality globally. Prevention strategies must address all aspects of… read more here.
Keywords: prevention; low dose; risk; cvd ... See more keywords
Cost-effectiveness of Low-Dose Computed Tomography With a Plasma-Based Biomarker for Lung Cancer Screening in China
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.13634
Abstract: This economic evaluation compares the cost-effectiveness of lung cancer screening strategies using low-dose computed tomography (LDCT) and a plasma-based biomarker or LDCT alone in a simulated population of Chinese adults with a history of smoking. read more here.
Keywords: lung cancer; computed tomography; dose computed; cancer screening ... See more keywords
Outcomes and Safety of Very-Low-Dose Edoxaban in Frail Patients With Atrial Fibrillation in the ELDERCARE-AF Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.28500
Abstract: Key Points Question Is very-low-dose edoxaban (15 mg/day) beneficial across frailty status among very elderly Japanese patients with atrial fibrillation considered ineligible for standard dose oral anticoagulants because of their high bleeding risk? Findings In… read more here.
Keywords: patients atrial; trial; dose edoxaban; atrial fibrillation ... See more keywords
Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease: A Systematic Review and Meta-analysis.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2019.1120
Abstract: Importance Use of low-dose aspirin for the primary prevention of cardiovascular events remains controversial because increased risk of bleeding may offset the overall benefit. Among major bleeding events, intracranial hemorrhage is associated with high mortality… read more here.
Keywords: risk; low dose; intracranial hemorrhage; hemorrhage ... See more keywords
Efficacy and Safety of 0.01% and 0.02% Atropine for the Treatment of Pediatric Myopia Progression Over 3 Years: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2023.2097
Abstract: Importance The global prevalence of myopia is predicted to approach 50% by 2050, increasing the risk of visual impairment later in life. No pharmacologic therapy is approved for treating childhood myopia progression. Objective To assess… read more here.
Keywords: dose atropine; myopia progression; progression; trial ... See more keywords
Effect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA surgery"
DOI: 10.1001/jamasurg.2019.2884
Abstract: Importance Current therapies for traumatic blood loss focus on hemorrhage control and blood volume replacement. Severe hemorrhagic shock, however, is associated with a state of arginine vasopressin (AVP) deficiency, and supplementation of this hormone may… read more here.
Keywords: low dose; blood product; blood; hemorrhagic shock ... See more keywords
Optimized low‐dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12797
Abstract: The current standard of care for colorectal cancer (CRC) is a combination of chemotherapeutics, often supplemented with targeted biological drugs. An urgent need exists for improved drug efficacy and minimized side effects, especially at late‐stage… read more here.
Keywords: optimized low; low dose; treatment; efficacy ... See more keywords