Efficacy of Systemic Chemotherapy in Patients With Low-grade Mucinous Appendiceal Adenocarcinoma
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DOI: 10.1001/jamanetworkopen.2023.16161
Abstract: Key Points Question Is fluoropyrimidine-based systemic chemotherapy effective in treating patients with inoperable low-grade mucinous appendiceal adenocarcinoma? Findings In this randomized crossover trial that included 24 patients, there was no significant difference in tumor growth… read more here.
Keywords: grade mucinous; appendiceal adenocarcinoma; mucinous appendiceal; low grade ... See more keywords
Association of MGMT Promotor Methylation With Survival in Low-grade and Anaplastic Gliomas After Alkylating Chemotherapy.
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DOI: 10.1001/jamaoncol.2023.0990
Abstract: Importance O6-methylguanine-DNA methyltransferase (MGMT [OMIM 156569]) promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas and is routinely used to guide treatment decisions. However, the utility of MGMT promoter status for low-grade… read more here.
Keywords: gliomas; idh; alkylating chemotherapy; ahr ... See more keywords
Efficient Low-Grade Heat Harvesting Enabled by Tuning the Hydration Entropy in an Electrochemical System.
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DOI: 10.1002/adma.202004717
Abstract: Harvesting of low-grade heat ( read more here.
Keywords: system; heat harvesting; heat; low grade ... See more keywords
An Ultrahigh‐Flux Nanoporous Graphene Membrane for Sustainable Seawater Desalination using Low‐Grade Heat
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DOI: 10.1002/adma.202109718
Abstract: Membrane distillation has attracted great attention in the development of sustainable desalination and zero‐discharge processes because of its possibility of recovering 100% water and the potential for integration with low‐grade heat, such as solar energy.… read more here.
Keywords: membrane; nanoporous graphene; desalination; graphene ... See more keywords
Low-Grade Waste Heat Enabled Over 80 L M-2 H-1 Interfacial Steam Generation Based on 3d Superhydrophilic Foam.
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DOI: 10.1002/adma.202211932
Abstract: Clean water scarcity and energy shortage have become urgent global problems due to population growth and human industrial development. Low-grade waste heat (LGWH) is a widely available and ubiquitous byproduct of human activities worldwide, which… read more here.
Keywords: water evaporation; grade waste; water; heat ... See more keywords
Presurgical cognitive status in patients with low‐grade glioma and epilepsy: Testing the effects of seizures, antiseizure medications, and tumor localization
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DOI: 10.1002/brb3.2560
Abstract: Low‐grade gliomas (LGGs) are frequently associated with epilepsy. There are few studies addressing the impact of seizures, antiseizure medications (ASMs), and lesion localization on presurgery cognitive functioning. read more here.
Keywords: antiseizure medications; localization; presurgical cognitive; seizures antiseizure ... See more keywords
ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.3858
Abstract: Treatment of both platinum resistant high grade (HG) and low‐grade (LG) ovarian cancer (OVCA) poses significant challenges as neither respond well to conventional chemotherapy leading to morbidity and mortality. Identification of novel agents that can… read more here.
Keywords: platinum; unfolded protein; grade ovarian; low grade ... See more keywords
Weighted correlation network analysis identifies multiple susceptibility loci for low‐grade glioma
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DOI: 10.1002/cam4.5368
Abstract: The current molecular classifications cannot completely explain the polarized malignant biological behavior of low‐grade gliomas (LGGs), especially for tumor recurrence. Therefore, we tried to identify suspicious hub genes related to tumor recurrence in LGGs. read more here.
Keywords: grade; analysis identifies; correlation network; network analysis ... See more keywords
Probing the phosphatidylinositol 3‐kinase/mammalian target of rapamycin pathway in gliomas: A phase 2 study of everolimus for recurrent adult low‐grade gliomas
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DOI: 10.1002/cncr.30909
Abstract: Activation of the phosphatidylinositol 3‐kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway is common in patients with low‐grade gliomas (LGGs), but agents that inhibit this pathway, including mTOR inhibitors, have not been studied in this population. read more here.
Keywords: gliomas; mammalian target; phosphatidylinositol kinase; target rapamycin ... See more keywords
Beyond the estrogen receptor: In search of predictive biomarkers for low‐grade serous ovarian cancer
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DOI: 10.1002/cncr.34658
Abstract: Low ‐ grade ovarian cancer (LGOC) comprises a rare group of tumors, including serous, mucinous, and endometrioid subtypes, that collectively account for 10% of ovarian cancer (OC) deaths and are histologically and molecularly distinct from… read more here.
Keywords: estrogen receptor; grade serous; ovarian cancer; low grade ... See more keywords
Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low‐grade ovarian carcinoma
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DOI: 10.1002/cncr.34661
Abstract: Advanced low‐grade ovarian carcinoma (LGOC) is difficult to treat. In several studies, high estrogen receptor (ER) protein expression was observed in patients with LGOC, which suggests that antihormonal therapy (AHT) is a treatment option. However,… read more here.
Keywords: estrogen receptor; activity; low grade; grade ovarian ... See more keywords