Development of New Antimicrobial Agents from Cationic PG-Surfactants Containing Oligo-Lys Peptides.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.8b00693
Abstract: Peptide gemini-surfactant (PG-surfactant), a kind of lipopeptide, is composed of a short linker peptide (X) between two alkyl-chain-modified Cys residues and peripheral peptides at the N-terminal (Y) and the C-terminal (Z) sides, respectively, of the… read more here.
Keywords: oligo lys; antimicrobial activity; low hemolytic; surfactants containing ... See more keywords
EnDL-HemoLyt: Ensemble Deep Learning-based Tool for Identifying Therapeutic Peptides with Low Hemolytic Activity.
Sign Up to like & getrecommendations! Published in 2023 at "IEEE journal of biomedical and health informatics"
DOI: 10.1109/jbhi.2023.3264941
Abstract: Low hemolytic therapeutic peptides have gained an edge over small molecule-based medicines. However, finding low hemolytic peptides in laboratory is time-consuming, costly and necessitates the use of mammalian red blood cells. Therefore, wet-lab researchers often… read more here.
Keywords: therapeutic peptides; low hemolytic; proposed framework; learning ... See more keywords
Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.693725
Abstract: Bacterial non-ribosomally produced peptides (NRPs) form a rich source of antibiotics, including more than 20 of these antibiotics that are used in the clinic, such as penicillin G, colistin, vancomycin, and chloramphenicol. Here we report… read more here.
Keywords: brevibacillin; novel antimicrobial; brevibacillin novel; hemolytic activity ... See more keywords