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   Articles with "low her2" as a keyword



Global Transcriptional Complexity of Estrogen Receptor–Low Positive Breast Cancers in the Prospective Swedish Population–Based SCAN-B Cohort

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recommendations! Published in 2025 at "Clinical Cancer Research"

DOI: 10.1158/1078-0432.ccr-24-3435

Abstract: Abstract Purpose: There is uncertainty whether estrogen receptor (ER)–low tumors with 1% to 10% IHC staining of nuclei represent a distinct molecular biological entity of breast cancer, posing significant challenges for their clinical management and… read more here.

Keywords: receptor; breast cancer; breast; low her2 ... See more keywords

Abstract PO4-02-02: Genomic Landscape of ER positive HER2-low early breast cancers in the FLEX Study: MammaPrint, BluePrint and whole transcriptome analysis

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.sabcs23-po4-02-02

Abstract: Background: Antibody-drug conjugates (ADCs) continue to emerge for the treatment of a new subset of patients with HER2-low breast cancer. There is limited evidence to demonstrate HER2-low tumors as a distinct biological subtype and why/if… read more here.

Keywords: blueprint; breast; low her2; her2 low ... See more keywords

Defining low-HER2 cancers using RNA quantification by next generation sequencing.

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recommendations! Published in 2024 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2024.42.16_suppl.e13044

Abstract: e13044 Background: The recent success of treatment with HER2-directed antibody-drug conjugate T-DXd (trastuzumab-deruxtecan) in treating low-HER2 expression breast cancer raises the possibility of similar success in other tumors that express similarly low levels of HER2.… read more here.

Keywords: cancer; low erbb2; low her2; her2 ... See more keywords

Characterization of the immune microenvironment and spatial phenotypes across HER2 subtypes in advanced or metastatic breast cancer.

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recommendations! Published in 2025 at "Journal of Clinical Oncology"

DOI: 10.1200/jco.2025.43.16_suppl.1037

Abstract: 1037 Background: Breast cancer is defined by HER2 and hormone receptors (HR) status, which influence the clinical outcomes. HER2-positive has been traditionally defined as HER2 overexpression on immunohistochemistry (IHC score of 3+) or 2+ and… read more here.

Keywords: breast cancer; low her2; her2 low; her2 ... See more keywords

Preliminary study on DCE-MRI radiomics analysis for differentiation of HER2-low and HER2-zero breast cancer

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recommendations! Published in 2024 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2024.1385352

Abstract: Purpose This study aims to evaluate the utility of radiomic features from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in distinguishing HER2-low from HER2-zero breast cancer. Patients and methods We retrospectively analyzed 118 MRI cases, including… read more here.

Keywords: low her2; her2 low; her2; dce mri ... See more keywords