How to face the low intrinsic sensitivity of 2D heteronuclear NMR with fast repetition techniques: go faster to go higher!
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4596
Abstract: Nuclear magnetic resonance (NMR) is one of the most widely used analytical techniques in numerous domains where molecules are objects of investigation. However, major limitations of multidimensional NMR experiments come from their low sensitivity and… read more here.
Keywords: fast repetition; low intrinsic; face low; heteronuclear nmr ... See more keywords
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aaz3140
Abstract: Low intrinsic efficacy can explain the reduced side effects of apparently biased μ-opioid receptor agonists. Opioids: Efficacy versus bias Because of its antinociceptive effects, the μ-opioid receptor (MOR) is an important target for pain management,… read more here.
Keywords: low intrinsic; mor; intrinsic efficacy; efficacy ... See more keywords