Low mutational load in pediatric medulloblastoma still translates into neoantigens as targets for specific T-cell immunotherapy.
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DOI: 10.1016/j.jcyt.2019.06.009
Abstract: BACKGROUND Medulloblastoma is the most common malignant brain tumor in childhood and adolescence. Although some patients present with distinct genetic alterations, such as mutated TP53 or MYC amplification, pediatric medulloblastoma is a tumor entity with… read more here.
Keywords: mutational load; low mutational; medulloblastoma; specific cell ... See more keywords
In vitro induction of neoantigen-specific T cells in myelodysplastic syndrome, a disease with low mutational burden.
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DOI: 10.1016/j.jcyt.2020.10.003
Abstract: Therapies that utilize immune checkpoint inhibition work by leveraging mutation-derived neoantigens and have shown greater clinical efficacy in tumors with higher mutational burden. Whether tumors with a low mutational burden are susceptible to neoantigen-targeted therapy… read more here.
Keywords: neoantigen specific; low mutational; specific cells; burden ... See more keywords
Low mutational load and high mutation rate variation in gut commensal bacteria
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DOI: 10.1371/journal.pbio.3000617
Abstract: Bacteria generally live in species-rich communities, such as the gut microbiota. Yet little is known about bacterial evolution in natural ecosystems. Here, we followed the long-term evolution of commensal Escherichia coli in the mouse gut.… read more here.
Keywords: mutational load; low mutational; mutation; mutation rate ... See more keywords