Epigenetic Profiles of Primary Endothelial Cells from Patients with Low VWF Levels
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DOI: 10.1182/blood-2018-99-116719
Abstract: Background Von Willebrand disease (VWD) type 1 is characterized by low von Willebrand factor (VWF) levels and mucocutaneous bleeding (MCB). Approximately 50% of patients with VWD type 1 exhibit mutations in VWF. However, a large… read more here.
Keywords: methylation; vwf levels; low vwf; endothelial cells ... See more keywords
Practice Patterns for Diagnosis of Type 1 Von Willebrand Disease and Effect of Age on Von Willebrand Factor Levels: A Single Institutional Retrospective Study
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DOI: 10.1182/blood-2018-99-119137
Abstract: Introduction Type 1 von Willebrand disease (VWD 1) accounts for ~75% of VWD. The National Heart, Lung, and Blood (NHLBI) VWD guidelines recommend VWF:Ag and VWF:RCo cut-off levels of 1 year (n=36) after initial lab… read more here.
Keywords: age; low vwf; vwf vwf; von willebrand ... See more keywords
Single Cell Transcriptional Analysis of Human Endothelial Colony Forming Cells from Patients with Low VWF Levels.
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DOI: 10.1182/blood.2021010683
Abstract: Von Willebrand Factor (VWF) plays a key role in normal hemostasis and deficiencies of VWF lead to clinically significant bleeding. We sought to identify novel modifiers of VWF levels in endothelial colony forming cells (ECFCs)… read more here.
Keywords: cell; patients low; scrna seq; vwf ... See more keywords
Endothelial Colony Forming Cells from Individuals with Low VWF Levels Demonstrate Impairment in Stimulated VWF Release
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DOI: 10.1182/blood.v130.suppl_1.21.21
Abstract: Background Von Willebrand factor (VWF) is an essential hemostatic protein and deficiencies of VWF predispose to mucocutaneous bleeding (MCB) such as seen in von Willebrand disease (VWD). VWD type 1 is characterized by incomplete penetrance… read more here.
Keywords: vwf levels; low vwf; vwf release; individuals low ... See more keywords