Respiratory pathogen colonization of dental plaque, the lower airways, and endotracheal tube biofilms during mechanical ventilation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Critical Care"
DOI: 10.1016/j.jcrc.2016.07.019
Abstract: Purpose: In mechanically ventilated patients, the endotracheal tube is an essential interface between the patient and ventilator, but inadvertently, it also facilitates the development of ventilator‐associated pneumonia (VAP) by subverting pulmonary host defenses. A number… read more here.
Keywords: lower airways; dental plaque; mechanical ventilation; plaque ... See more keywords
Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135505
Abstract: The lower airways (larynx to alveoli) are protected by a complex array of neural networks that regulate respiration and airway function. Harmful stimuli trigger defensive responses such as apnea, cough and bronchospasm by activating a… read more here.
Keywords: lower airways; derived nociceptors; anatomy; gene expression ... See more keywords
Acquisition and adaptation of the airway microbiota in the early life of cystic fibrosis patients
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Pediatrics"
DOI: 10.1186/s40348-016-0067-1
Abstract: Cystic fibrosis (CF) is a genetic disease in which bacterial infections of the airways play a major role in the long-term clinical outcome. In recent years, a number of next-generation sequencing (NGS)-based studies aimed at… read more here.
Keywords: cystic fibrosis; lower airways; early life; microbiota early ... See more keywords
Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006798
Abstract: The cystic fibrosis (CF) lung microbiome has been studied in children and adults; however, little is known about its relationship to early disease progression. To better understand the relationship between the lung microbiome and early… read more here.
Keywords: cystic fibrosis; lower airways; disease; lung microbiome ... See more keywords
Epithelial immune activation and intracellular invasion by non-typeable Haemophilus influenzae
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1141798
Abstract: Type-2 low asthma affects 30-50% of people with severe asthma and includes a phenotype characterized by sputum neutrophilia and resistance to corticosteroids. Airways inflammation in type-2 low asthma or COPD is potentially driven by persistent… read more here.
Keywords: haemophilus influenzae; lower airways; invasion; intracellular invasion ... See more keywords
Identification of Novel Genes and Biological Pathways That Overlap in Infectious and Nonallergic Diseases of the Upper and Lower Airways Using Network Analyses
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.01352
Abstract: Previous genetic studies on susceptibility to otitis media and airway infections have focused on immune pathways acting within the local mucosal epithelium, and outside of allergic rhinitis and asthma, limited studies exist on the overlaps… read more here.
Keywords: upper lower; otitis media; network; lower airways ... See more keywords
Transcriptomic analysis of asthma and allergic rhinitis reveals CST1 as a biomarker of unified airways
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1048195
Abstract: Background Allergic rhinitis (AR) is an important risk factor for the development of asthma. The “unified airway” theory considers the upper and lower airways as a morphological and functional whole. However, studies exploring biomarkers linking… read more here.
Keywords: development asthma; asthma; analysis; lower airways ... See more keywords
Temporal changes of the respiratory microbiota as cats transition from health to experimental acute and chronic allergic asthma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.983375
Abstract: In humans, deviation from a core airway microbiota may predispose to development, exacerbation, or progression of asthma. We proposed to describe microbiota changes using 16 rRNA sequencing in samples from the upper and lower airways,… read more here.
Keywords: health; allergic asthma; asthma; lower airways ... See more keywords
Characterization of the Lower Airways and Oral Microbiota in Healthy Young Persons in the Community
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11030841
Abstract: Lower airway dysbiosis contributes to disease pathogenesis in respiratory diseases. However, little is known regarding the microbiota of lower airways or the oral cavity of healthy young persons. To address this gap, 25 healthy persons… read more here.
Keywords: microbiota; lower airways; young persons; healthy young ... See more keywords