Depletion of somatic mutations in splicing-associated sequences in cancer genomes
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DOI: 10.1186/s13059-017-1337-5
Abstract: BackgroundAn important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection,… read more here.
Keywords: selection; somatic mutations; lower ssm; ssm density ... See more keywords