Discovery of N-arylsulfonyl-indole-2-carboxamide Derivatives as Potent, Selective, and Orally Bioavailable Fructose-1,6-Bisphosphatase Inhibitors- Design, Synthesis, In Vivo Glucose Lowering Effects, and X-ray Crystal Complex Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00726
Abstract: Liver fructose-1,6-bisphosphatase (FBPase) is a key enzyme in the gluconeogenesis pathway. Inhibiting FBPase activity represents a potential treatment for type 2 diabetes mellitus. A series of novel N-arylsulfonyl-4-arylamino-indole-2-carboxamide derivatives have been disclosed as FBPase inhibitors.… read more here.
Keywords: carboxamide derivatives; indole carboxamide; ray crystal; fructose bisphosphatase ... See more keywords
Glucose‐lowering effects and mechanisms of the bile acid‐sequestering resin sevelamer
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DOI: 10.1111/dom.13272
Abstract: Sevelamer, a non‐absorbable amine‐based resin used for treatment of hyperphosphataemia, has been demonstrated to have a marked bile acid‐binding potential alongside beneficial effects on lipid and glucose metabolism. The aim of this study was to… read more here.
Keywords: sevelamer; resin; effects mechanisms; bile acid ... See more keywords
POS1130 PHARMACOKINETICS AND SERUM URATE LOWERING EFFECTS OF AR882, A NOVEL, POTENT AND SELECTIVE URICOSURIC AGENT, IN PATIENTS WITH GOUT
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.1284
Abstract: AR882 is a novel, potent and selective uric acid transporter 1 (URAT1) inhibitor in Phase 2 development for the treatment of hyperuricemia and gout. In Phase 1 healthy subject studies, AR882 demonstrated good dose proportionality,… read more here.
Keywords: sua; arthrosi therapeutics; lowering effects; sua levels ... See more keywords
Postprandial glucose-lowering effects by sago (Metroxylon sagu Rottb.) resistant starch in spontaneously type 2 diabetes, Goto-Kakizaki rat.
Sign Up to like & getrecommendations! Published in 2023 at "Nutrition and health"
DOI: 10.1177/02601060231152060
Abstract: Introduction: The beneficial effects of resistant starch (RS) consumption on health in terms of reducing postprandial hyperglycaemia are evident. However, the potential of local Sarawak sago RS in regulating glucose has not been extensively studied.… read more here.
Keywords: spontaneously type; glucose lowering; type diabetes; lowering effects ... See more keywords
Evaluation of surgical treatment of gout—A retrospective study on 28 cases with tophi
Sign Up to like & getrecommendations! Published in 2025 at "PLOS ONE"
DOI: 10.1371/journal.pone.0313586
Abstract: Introduction The efficacy, safety, optimal timing, and urate-lowering effects of surgical interventions in gout management remain poorly understood. This study aims to fill this gap by evaluating the role of surgery in treating gout patients… read more here.
Keywords: gout; evaluation surgical; lowering effects; urate lowering ... See more keywords
Hederagenin’s uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis
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DOI: 10.1371/journal.pone.0326317
Abstract: This study explored the uric acid-lowering effects of hederagenin (HD) through molecular docking analysis and a chronic hyperuricemia (HUA) mouse model. Molecular docking was performed to evaluate HD’s interactions key urate-regulating proteins, including xanthine oxidase… read more here.
Keywords: molecular docking; analysis; acid lowering; lowering effects ... See more keywords
The glucose lowering effects of CL 316,243 dissipate with repeated use and are rescued bycilostamide
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15187
Abstract: Repeated activation of the beta 3 adrenergic receptor (β3AR) with the agonist CL 316,243 (CL) results in remodeling of white adipose tissue (WAT) characterized by increased mitochondrial enzymes and expression of uncoupling protein 1 (UCP1).… read more here.
Keywords: blood glucose; repeated treatment; glucose lowering; treatment ... See more keywords
The Lipid-lowering Effects and Associated Mechanisms of Dietary Phytosterol Supplementation.
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DOI: 10.2174/1381612823666170725142337
Abstract: Phytosterols (PS) are plant-based structural analogous of mammalian cholesterol that have been shown to lower blood cholesterol concentrations by ~10%, although inter-individual response to PS supplementation due to subject-specific metabolic and genetic factors is evident.… read more here.
Keywords: supplementation; cholesterol; effects associated; lipid lowering ... See more keywords
The lipid-lowering effects of fenugreek gum, hawthorn pectin, and burdock inulin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2023.1149094
Abstract: Objective The present study aimed to investigate the lipid-lowering effects and mechanisms of fenugreek gum (FG), hawthorn pectin (HP), and burdock inulin (BI) on high-fat diet (HFD)-induced hyperlipidemic rats. Methods In this study, high-fat diet… read more here.
Keywords: hawthorn pectin; pectin burdock; lipid lowering; lowering effects ... See more keywords
Effect of Fixation Methods on Biochemical Characteristics of Green Teas and Their Lipid-Lowering Effects in a Zebrafish Larvae Model
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11111582
Abstract: Fixation is a key process contributing to different flavors of green tea and pan-fire and steam were the common fixation methods applied conventionally. In this study, pan-fired green tea (PGT) and steamed green tea (SGT)… read more here.
Keywords: fixation methods; sgt; lipid lowering; green tea ... See more keywords