The oxidized‐LDL/LOX‐1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34134
Abstract: Epidemiological relationships between cancer and cardiovascular diseases have been reported, but a molecular basis remains unclear. Some proteoglycans that strongly bind low‐density‐lipoprotein (LDL) are abundant both in atherosclerotic regions and in high metastatic‐tumor tissue. LDL… read more here.
Keywords: lox; metastasis; oxidized ldl; tumor ... See more keywords
Upregulated LOX and increased collagen content associated with aggressive clinicopathological features and unfavorable outcome in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28669
Abstract: Collagen is a core protein that maintains the homeostasis of the extracellular matrix (ECM), and its dysregulation in human cancers has attracted increasing attention. In tumors, increased lysyl oxidase (LOX)‐catalyzed collagen cross‐linking plays a critical… read more here.
Keywords: collagen; cell carcinoma; oral squamous; squamous cell ... See more keywords
LOX suppresses the inflammatory response in ACL fibroblasts and promotes tissue regeneration by targeting myotrophin via the NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of tissue engineering and regenerative medicine"
DOI: 10.1002/term.3077
Abstract: Anterior cruciate ligament (ACL) regeneration is severely affected by the injury-induced overexpression of matrix metalloproteinases (MMPs) and downregulation of lysyl oxidase (LOX). Previous studies have focused on how the expression of MMPs and downregulation of… read more here.
Keywords: regeneration; inflammatory response; lox; expression ... See more keywords
In Vivo Evaluation and Dosimetry Estimate for a High Affinity Affibody PET Tracer Targeting PD-L1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-020-01544-2
Abstract: Purpose In vivo imaging of programmed death ligand 1 (PD-L1) during immunotherapy could potentially monitor changing PD-L1 expression and PD-L1 expression heterogeneity within and across tumors. Some protein constructs can be used for same-day positron… read more here.
Keywords: affibody; affinity; lox; pet tracer ... See more keywords
Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.05.014
Abstract: Designing of hybrid drugs with specific multitarget profile is a promising line of attack against inflammation. In light of this, a series of benzimidazole scaffold based hybrid molecules were designed by integrating benzimidazoles (containing pharmacophoric… read more here.
Keywords: hybrid molecules; scaffold based; benzimidazole scaffold; lox ... See more keywords
Intracellular Role for the Matrix-Modifying Enzyme Lox in Regulating Transcription Factor Subcellular Localization and Activity in Muscle Regeneration.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.04.002
Abstract: Integration of extracellular matrix (ECM)-derived cues into transcriptional programs is essential primarily in rapidly morphing environments, such as regenerating tissues. Here, we demonstrate that lysyl oxidase (Lox), known for its ECM-modifying activities, primarily collagen crosslinking,… read more here.
Keywords: muscle regeneration; lox; transcription factor; factor ... See more keywords
Design, synthesis, biological evaluation and docking study of novel indole-2-amide as anti-inflammatory agents with dual inhibition of COX and 5-LOX.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.07.004
Abstract: In this work, a series of novel indole-2-amide compounds were designed, synthesized, characterized and the anti-inflammatory activity in vivo were evaluated. Compounds 8a, 10b, 12h, and 12l exhibited marked anti-inflammatory activity in 2,4-Dinitrofluorobenzenethe (DNFB) - induced… read more here.
Keywords: anti inflammatory; novel indole; indole amide; lox ... See more keywords
Pharmacological evaluation and molecular docking of new di‐tert‐butylphenol compound, LQFM‐091, a new dual 5‐LOX/COX inhibitor
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.06.006
Abstract: Abstract Dual 5‐LOX/COX inhibitors are potential new dual drugs to treat inflammatory conditions. This research aimed to design, synthesis and to evaluate the anti‐inflammatory and antinociceptive effects of the new compound, which is derived from… read more here.
Keywords: lox cox; lox; new dual; compound ... See more keywords
DOPG small unilamellar vesicles function as nano-carriers targeting the clustered lectin-like oxidized LDL receptor (LOX-1) on the cell surface
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.03.014
Abstract: Abstract The lectin-like oxidized low-density lipoprotein (OxLDL) receptor (LOX-1) is the primary OxLDL receptor of vascular endothelial cells. OxLDL binding to LOX-1 promotes atherogenesis by upregulating LOX-1 expression to further sensitize cells against OxLDL. In… read more here.
Keywords: surface; lectin like; like oxidized; receptor ... See more keywords
Screening for natural inhibitors of 5-lipoxygenase from Zi-shen pill extract by affinity ultrafiltration coupled with ultra performance liquid chromatography-mass spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2020.112733
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Zi-shen pill (ZSP), a traditional Chinese medicine, is widely used for the treatment of benign prostatic hyperplasia (BPH) and has remarkable curative effect. AIM OF THE STUDY To screen the potential 5-Lipoxygenase(5-LOX) inhibitors… read more here.
Keywords: affinity ultrafiltration; mass spectrometry; lox;
LOX‐1 promotes right ventricular hypertrophy in hypoxia‐exposed rats
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.02.016
Abstract: Aim: Chronic hypoxia leads to right ventricular hypertrophy (RVH). RVH is believed to result from hypoxia‐induced pulmonary hypertension. However, if hypoxia impacts RVH directly awaits clarification. Hypoxia triggers oxidative stress, and lectin‐like oxidized low‐density lipoprotein… read more here.
Keywords: right ventricular; lox; hypertrophy; hypoxia ... See more keywords