Lysyl Oxidase (LOX) Family Members: Rationale and Their Potential as Therapeutic Targets for Liver Fibrosis
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DOI: 10.1002/hep.31236
Abstract: The cross‐linking of structural extracellular matrix (ECM) components, especially fibrillar collagens and elastin, is strongly implicated in fibrosis progression and resistance to fibrosis reversal. Lysyl oxidase family members (LOX and LOXL1 [lysyl oxidase‐like 1], LOXL2… read more here.
Keywords: fibrosis; liver fibrosis; family members; family ... See more keywords
Correlation of Matrisome-Associatted Gene Expressions with LOX Family Members in Astrocytomas Stratified by IDH Mutation Status
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DOI: 10.3390/ijms23179507
Abstract: Tumor cell infiltrative ability into surrounding brain tissue is a characteristic of diffusely infiltrative astrocytoma and is strongly associated with extracellular matrix (ECM) stiffness. Collagens are the most abundant ECM scaffolding proteins and contribute to… read more here.
Keywords: family members; expression; lox family; idh mutation ... See more keywords
Lysyl Oxidase Family Proteins: Prospective Therapeutic Targets in Cancer
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DOI: 10.3390/ijms232012270
Abstract: The lysyl oxidase (LOX) family, consisting of LOX and LOX-like proteins 1–4 (LOXL1–4), is responsible for the covalent crosslinking of collagen and elastin, thus maintaining the stability of the extracellular matrix (ECM) and functioning in… read more here.
Keywords: family; lysyl oxidase; lox family; tumor ... See more keywords